[HTML][HTML] Broadening the horizon: potential applications of CAR-T cells beyond current indications
H Karsten, L Matrisch, S Cichutek, W Fiedler… - Frontiers in …, 2023 - frontiersin.org
Engineering immune cells to treat hematological malignancies has been a major focus of
research since the first resounding successes of CAR-T-cell therapies in B-ALL. Several …
research since the first resounding successes of CAR-T-cell therapies in B-ALL. Several …
Integration of ζ-deficient CARs into the CD3ζ gene conveys potent cytotoxicity in T and NK cells
J Kath, C Franke, V Drosdek, W Du, V Glaser… - Blood, 2024 - ashpublications.org
Chimeric antigen receptor (CAR)-redirected immune cells hold significant therapeutic
potential for oncology, autoimmune diseases, transplant medicine, and infections. All …
potential for oncology, autoimmune diseases, transplant medicine, and infections. All …
[HTML][HTML] Increasing Gene Editing Efficiency via CRISPR/Cas9-or Cas12a-Mediated Knock-In in Primary Human T Cells
N Kruglova, M Shepelev - Biomedicines, 2024 - mdpi.com
T lymphocytes represent a promising target for genome editing. They are primarily modified
to recognize and kill tumor cells or to withstand HIV infection. In most studies, T cell genome …
to recognize and kill tumor cells or to withstand HIV infection. In most studies, T cell genome …
[HTML][HTML] Differential carbonic anhydrase activities control EBV-induced B-cell transformation and lytic cycle reactivation
Epstein-Barr virus (EBV) contributes to~ 1% of all human cancers including several B-cell
neoplasms. A characteristic feature of EBV life cycle is its ability to transform metabolically …
neoplasms. A characteristic feature of EBV life cycle is its ability to transform metabolically …
[HTML][HTML] Leveraging oncovirus-derived antigen against the viral malignancies in adoptive cell therapies
W Zhang, M Zeng, Y Li, L Yu - Biomarker …, 2024 - biomarkerres.biomedcentral.com
Adoptive cell therapies (ACTs) have revolutionized cancer immunotherapy, prompting
exploration into their application against oncoviruses. Oncoviruses such as human …
exploration into their application against oncoviruses. Oncoviruses such as human …
Are we ready for personalized CAR‐T therapy?
A Strzelec, G Helbig - European Journal of Haematology, 2024 - Wiley Online Library
The future of chimeric antigen receptor T (CAR‐T) therapy remains unclear. New studies are
constantly being published confirming the efficacy and favorable safety profile of its …
constantly being published confirming the efficacy and favorable safety profile of its …