Abstract In recent years, 5-methylcytosine (m5C) RNA modification has emerged as a key
player in regulating RNA metabolism and function through coding as well as non-coding …

The mitochondrial ribosome (mitoribosome) is a multicomponent machine that has unique
structural features. Biogenesis of the human mitoribosome includes correct maturation and …

Ribosome biogenesis requires auxiliary factors to promote folding and assembly of
ribosomal proteins and RNA. Particularly, maturation of the peptidyl transferase center (PTC) …

Mitochondria contain their own genetic information and a dedicated translation system to
express it. The mitochondrial ribosome is assembled from mitochondrial-encoded RNA and …

Mitochondrial ribosomes (mitoribosomes) synthesize a critical set of proteins essential for
oxidative phosphorylation. Therefore, mitoribosomal function is vital to the cellular energy …

Assembly of the mitoribosome is largely enigmatic and involves numerous assembly factors.
Little is known about their function and the architectural transitions of the pre-ribosomal …

Mammalian mitochondrial ribosomes (mitoribosomes) synthesize a small subset of proteins,
which are essential components of the oxidative phosphorylation machinery. Therefore, their …

Many cellular processes, including ribosome biogenesis, are regulated through post-
transcriptional RNA modifications. Here, a genome-wide analysis of the human …

Mitochondrial gene expression relies on mitoribosomes to translate mitochondrial mRNAs.
The biogenesis of mitoribosomes is an intricate process involving multiple assembly factors …

As ancient bacterial endosymbionts of eukaryotic cells, mitochondria have retained their
own circular DNA as well as protein translation system including mitochondrial ribosomes …