The consequences of SARS-CoV-2 infection on the musculoskeletal system represent a
dangerous knowledge gap. Aging patients are at added risk for SARS-CoV-2 infection; …

Ideally, humane endpoints allow for early termination of experiments by minimizing an
animal's discomfort, distress and pain, while ensuring that scientific objectives are reached …

Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia characterized by
granulomatous lesions containing pathological CD207+ dendritic cells (DCs) with persistent …

Hematopoietic stem cell gene therapy has become a successful therapeutic strategy for
some inherited genetic disorders. Pre-clinical toxicity studies performed to support the …

Managing postoperative pain in rodents is an important part of any animal care and use
program, and identifying an optimal analgesic plan for a surgical procedure is critical to …

There is a lack of safe and effective non-opioid medications for the treatment of opioid
addiction. Aquaporin-4 (AQP4), a water channel protein expressed in astrocytes, regulates …

The types of changes in physical appearance and behavior that occur in elderly people
similarly develop in elderly animals. Signs and symptoms that might cause concern in …

Background Exposure to high doses of total body irradiation (TBI) may lead to the
development of acute radiation syndrome (ARS). This study was conducted to establish an …

Interleukin (IL) 18 is a potent pro-inflammatory cytokine that is activated upon caspase 1
cleavage of the latent precursor, pro-IL18. Therapeutic T cell armoring with IL18 promotes …

Allogeneic stem cell transplantation (alloSCT) is utilised to cure haematological
malignancies through a combination of conditioning regimen intensity and immunological …