[HTML][HTML] Biological factors underpinning suicidal behaviour: an update

MN Abou Chahla, MI Khalil, S Comai, L Brundin… - Brain sciences, 2023 - mdpi.com
Suicide, a global health burden, represents the 17th leading cause of death worldwide
(1.3%), but the 4th among young people aged between 15 and 29 years of age, according to …

[HTML][HTML] The tryptophan-kynurenine metabolic system is suppressed in cuprizone-induced model of demyelination simulating progressive multiple sclerosis

H Polyák, Z Galla, N Nánási, EK Cseh, C Rajda… - Biomedicines, 2023 - mdpi.com
Progressive multiple sclerosis (MS) is a chronic disease with a unique pattern, which is
histologically classified into the subpial type 3 lesions in the autopsy. The lesion is also …

[HTML][HTML] Research Progress on the role of RNA m6A modification in glial cells in the regulation of neurological diseases

S You, X Su, J Ying, S Li, Y Qu, D Mu - Biomolecules, 2022 - mdpi.com
Glial cells are the most abundant and widely distributed cells that maintain cerebral
homeostasis in the central nervous system. They mainly include microglia, astrocytes, and …

Neuropsychiatric symptoms and microglial activation in patients with Alzheimer disease

CS Aguzzoli, PCL Ferreira, G Povala… - JAMA Network …, 2023 - jamanetwork.com
Importance Neuropsychiatric symptoms are commonly encountered and are highly
debilitating in patients with Alzheimer disease. Understanding their underpinnings has …

Increased immune cell and altered microglia and neurogenesis transcripts in an Australian schizophrenia subgroup with elevated inflammation

HF North, C Weissleder, JM Fullerton, MJ Webster… - Schizophrenia …, 2022 - Elsevier
We previously identified a subgroup of schizophrenia cases (~ 40%) with heightened
inflammation in the neurogenic subependymal zone (SEZ)(North et al., 2021b). This …

[HTML][HTML] Mechanistic studies of gypenosides in microglial state transition and its implications in depression-like behaviors: role of TLR4/MyD88/NF-κB signaling

LH Cao, YY Zhao, M Bai, D Geliebter… - Frontiers in …, 2022 - frontiersin.org
Depression is a prevalent psychiatric disorder. Microglial state transition has been found in
many neurological disorders including depression. Gypenosides (Gypenosides I-LXXVIII …

[HTML][HTML] Suicide, neuroinflammation and other physiological alterations

SP Bengoechea-Fortes, MJ Ramírez-Expósito… - European archives of …, 2024 - Springer
Suicide is considered one of the major public health problems worldwide, being the second
leading cause of death in the 15–29 age group. It is estimated that every 40s someone in the …

[PDF][PDF] The tryptophan-kynurenine metabolic system is suppressed in cuprizone-induced model of demyelination simulating progressive multiple sclerosis., 2023, 11 …

H Polyák, Z Galla, N Nánási, EK Cseh… - DOI: https://doi. org …, 2023 - researchgate.net
Progressive multiple sclerosis (MS) is a chronic disease with a unique pattern, which is
histologically classified into the subpial type 3 lesions in the autopsy. The lesion is also …

The Janus face of antipsychotics in glial cells: Focus on glioprotection

I Schmitz, A da Silva, LD Bobermin… - Experimental …, 2023 - journals.sagepub.com
Antipsychotics are commonly prescribed to treat several neuropsychiatric disorders,
including schizophrenia, mania in bipolar disorder, autism spectrum disorder, delirium, and …

The missing piece? A case for microglia's prominent role in the therapeutic action of anesthetics, ketamine, and psychedelics

J VanderZwaag, T Halvorson, K Dolhan… - Neurochemical …, 2023 - Springer
There is much excitement surrounding recent research of promising, mechanistically novel
psychotherapeutics–psychedelic, anesthetic, and dissociative agents–as they have …