Common causes of hearing loss in humans-exposure to loud noise or ototoxic drugs and
aging-often damage sensory hair cells, reflected as elevated thresholds on the clinical …

The classic view of sensorineural hearing loss has been that the primary damage targets are
hair cells and that auditory nerve loss is typically secondary to hair cell degeneration …

Age-related hearing loss arises from irreversible damage in the inner ear, where sound is
transduced into electrical signals. Prior human studies suggested that sensory-cell loss is …

The noise-induced and age-related loss of synaptic connections between auditory-nerve
fibers and cochlear hair cells is well-established from histopathology in several mammalian …

Recent work suggests that hair cells are not the most vulnerable elements in the inner ear;
rather, it is the synapses between hair cells and cochlear nerve terminals that degenerate …

The classic view of sensorineural hearing loss (SNHL) is that the “primary” targets are hair
cells, and that cochlear-nerve loss is “secondary” to hair cell degeneration. Our recent work …

Tinnitus, reduced sound-level tolerance, and difficulties hearing in noisy environments are
the most common complaints associated with sensorineural hearing loss in adult …

Sensorineural hearing loss induced by noise or ototoxic drug exposure reduces the neural
activity transmitted from the cochlea to the central auditory system. Despite a reduced …

Recent animal work has suggested that cochlear synapses are more vulnerable than hair
cells in both noise-induced and age-related hearing loss. This synaptopathy is invisible in …

Cochlear synaptic loss, rather than hair cell death, is the earliest sign of damage in both
noise-and age-related hearing impairment (;). Here, we compare cochlear aging after two …