Signaling pathways and intervention therapies in sepsis
Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …
systemic inflammatory and immune response to infection. Over decades, advanced …
Endothelial responses in sepsis
J Joffre, J Hellman, C Ince… - American journal of …, 2020 - atsjournals.org
Endothelial cells (ECs) are vascular, nonconventional immune cells that play a major role in
the systemic response after bacterial infection to limit its dissemination. Triggered by …
the systemic response after bacterial infection to limit its dissemination. Triggered by …
[HTML][HTML] Large-scale multi-omic analysis of COVID-19 severity
We performed RNA-seq and high-resolution mass spectrometry on 128 blood samples from
COVID-19-positive and COVID-19-negative patients with diverse disease severities and …
COVID-19-positive and COVID-19-negative patients with diverse disease severities and …
Derivation, validation, and potential treatment implications of novel clinical phenotypes for sepsis
Importance Sepsis is a heterogeneous syndrome. Identification of distinct clinical
phenotypes may allow more precise therapy and improve care. Objective To derive sepsis …
phenotypes may allow more precise therapy and improve care. Objective To derive sepsis …
The artificial intelligence clinician learns optimal treatment strategies for sepsis in intensive care
Sepsis is the third leading cause of death worldwide and the main cause of mortality in
hospitals,–, but the best treatment strategy remains uncertain. In particular, evidence …
hospitals,–, but the best treatment strategy remains uncertain. In particular, evidence …
Sepsis and septic shock
Sepsis is a common condition that is associated with unacceptably high mortality and, for
many of those who survive, long-term morbidity. Increased awareness of the condition …
many of those who survive, long-term morbidity. Increased awareness of the condition …
Sepsis: The evolution in definition, pathophysiology, and management
B Gyawali, K Ramakrishna… - SAGE open …, 2019 - journals.sagepub.com
There has been a significant evolution in the definition and management of sepsis over the
last three decades. This is driven in part due to the advances made in our understanding of …
last three decades. This is driven in part due to the advances made in our understanding of …
Personalized mechanical ventilation in acute respiratory distress syndrome
A personalized mechanical ventilation approach for patients with adult respiratory distress
syndrome (ARDS) based on lung physiology and morphology, ARDS etiology, lung imaging …
syndrome (ARDS) based on lung physiology and morphology, ARDS etiology, lung imaging …
Sepsis-induced coagulopathy and disseminated intravascular coagulation
Disseminated intravascular coagulation (DIC) has been recognized as a deadly
complication in sepsis, and its early recognition followed by appropriate management of the …
complication in sepsis, and its early recognition followed by appropriate management of the …
IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome
S Kang, T Tanaka, H Inoue, C Ono… - Proceedings of the …, 2020 - National Acad Sciences
Cytokine release syndrome (CRS) is a life-threatening complication induced by systemic
inflammatory responses to infections, including bacteria and chimeric antigen receptor T cell …
inflammatory responses to infections, including bacteria and chimeric antigen receptor T cell …