Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal
monogenic disorder. It has large inter-and intra-familial variability explained to a large extent …

Dry eye disease (DED) is a multifactorial disorder in which the eyes respond to minor stimuli
with abnormal sensations, such as dryness, blurring, foreign body sensation, discomfort …

Abstract Polycystin-2 (PC2), a calcium-activated cation TRP channel, is involved in diverse
Ca2+ signaling pathways. Malfunctioning Ca2+ regulation in PC2 causes autosomal …

Mechanical forces associated with fluid flow and/or circumferential stretch are sensed by
renal epithelial cells and contribute to both adaptive or disease states. Non‐selective stretch …

Abstract Background. Inulin/sinistrin (I/S) clearance is a gold standard for an accurate
assessment of glomerular filtration rate (GFR). Here we describe and validate an approach …

The first genuine high-resolution single particle cryo-electron microscopy structure of a
membrane protein determined was a transient receptor potential (TRP) ion channel, TRPV1 …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 or
PKD2, which encode polycystin-1 and polycystin-2, respectively. Rodent models are …

The use of the colorimetric Jaffé method for the measurement of creatinine in mouse and rat
plasma has been criticized as prior studies have shown a dramatic overestimation. We …

Renal primary cilia are sensory antennas required for the maintenance of normal epithelial
differentiation and proliferation in the kidney, but they also have a potential role in epithelial …

Polycystin-2 (also called TRPP2), an integral membrane protein mutated in patients with
cystic kidney disease, is located in the primary cilium where it is thought to transmit …