During the past two decades, induced pluripotent stem cells (iPSCs) have been widely used
to study mechanisms of human neural development, disease modeling, and drug discovery …

Brain organoids are derived from induced pluripotent stem cells and embryonic stem cells
under 3-dimensional culture condition. The generation of organoid requires the self …

Human cerebral organoids, derived from induced pluripotent stem cells, offer a unique in
vitro research window to the development of the cerebral cortex. However, a key player in …

Progressive accumulation of α-Synuclein (αSyn) in Lewy bodies (LBs) and loss of
dopaminergic (DA) neurons are the hallmark pathological features of Parkinson's disease …

Secretases are a group of proteases that are major drug targets considered for the
prevention and treatment of Alzheimer's disease (AD). Secretases do not only process the …

Cholesterol is important for membrane integrity and cell signaling, and dysregulation of the
distribution of cellular cholesterol is associated with numerous diseases, including …

Understanding the complexities of the human brain and its associated disorders poses a
significant challenge in neuroscience. Traditional research methods have limitations in …

The neuro-physiological properties of individuals with genetic pre-disposition to
neurological disorders are largely unknown. Here we aimed to explore these properties …

Abstract Trisomy 21 (T21) causes Down syndrome and an early-onset form of Alzheimer's
disease (AD). Here, we used human induced pluripotent stem cells (hiPSCs) along with …

Understanding the role of small, soluble aggregates of beta-amyloid (Aβ) and tau in
Alzheimer's disease (AD) is of great importance for the rational design of preventative …