There are four members of the JAK family and seven of the STAT family in mammals. The
JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth …

Liver cancer is the second most lethal cancer in the world with limited treatment options.
Hepatocellular carcinoma (HCC), which accounts for more than 80% of all liver cancers, has …

Signal transducer and activator of transcription 4 (STAT4) is a member of the STAT family
and localizes to the cytoplasm. STAT4 is phosphorylated after a variety of cytokines bind to …

Much progress has been made in the identification of specific human gene variants that
contribute to enhanced susceptibility or resistance to viral diseases. Herein we review …

Hepatitis B virus (HBV) is a challenge for global health services, affecting millions and
leading thousands to end-stage liver disease each year. This comprehensive review …

Hedgehog (Hh) signaling plays a critical role in liver development, regeneration, injury
repair, and carcinogenesis. Activation of Hh signaling has been observed in patients with …

The clinical outcome of hepatitis B virus (HBV) infection depends on the success or failure of
the immune responses to HBV, and varies widely among individuals, ranging from …

Abstract Background and Aims Cirrhosis is characterized by extensive fibrosis of the liver
and is a major cause of liver‐related mortality. Cirrhosis is partially heritable but genetic …

Host gene variants may influence the natural history of hepatitis B virus (HBV) infection. The
human leukocyte antigen (HLA) system, the major histocompatibility complex (MHC) in …

Summary Background Hepatitis B virus (HBV) infection is a serious global health burden.
TRIM26 has been reported to affect hepatitis C virus replication. Aims To manifest the role of …