Doxorubicin—an agent with multiple mechanisms of anticancer activity

M Kciuk, A Gielecińska, S Mujwar, D Kołat… - Cells, 2023 - mdpi.com
Doxorubicin (DOX) constitutes the major constituent of anti-cancer treatment regimens
currently in clinical use. However, the precise mechanisms of DOX's action are not fully …

Elastin-like polypeptides for biomedical applications

AK Varanko, JC Su, A Chilkoti - Annual review of biomedical …, 2020 - annualreviews.org
Elastin-like polypeptides (ELPs) are stimulus-responsive biopolymers derived from human
elastin. Their unique properties—including lower critical solution temperature phase …

Biomimetic diselenide‐bridged mesoporous organosilica nanoparticles as an X‐ray‐responsive biodegradable carrier for chemo‐immunotherapy

D Shao, F Zhang, F Chen, X Zheng, H Hu… - Advanced …, 2020 - Wiley Online Library
Chemotherapy causes off‐target toxicity and is often ineffective against solid tumors.
Targeted and on‐demand release of chemotherapeutics remains a challenge. Here, cancer …

Walking dead tumor cells for targeted drug delivery against lung metastasis of triple‐negative breast cancer

Z Zhao, L Fang, P Xiao, X Sun, L Zhou, X Liu… - Advanced …, 2022 - Wiley Online Library
Lung metastasis is challenging in patients with triple‐negative breast cancer (TNBC).
Surgery is always not available due to the dissemination of metastatic foci and most drugs …

Chemotherapeutic drug-induced immunogenic cell death for nanomedicine-based cancer chemo–immunotherapy

M Jiang, J Zeng, L Zhao, M Zhang, J Ma, X Guan… - Nanoscale, 2021 - pubs.rsc.org
Chemotherapy has been a conventional paradigm for cancer treatment, and multifarious
chemotherapeutic drugs have been widely employed for decades with significant …

Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

I Vanmeerbeek, J Sprooten, D De Ruysscher… - …, 2020 - Taylor & Francis
The term 'immunogenic cell death'(ICD) denotes an immunologically unique type of
regulated cell death that enables, rather than suppresses, T cell-driven immune responses …

Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy

MP Vincent, JO Navidzadeh, S Bobbala, EA Scott - Cancer Cell, 2022 - cell.com
Nanomaterials and targeted drug delivery vehicles improve the therapeutic index of drugs
and permit greater control over their pharmacokinetics, biodistribution, and bioavailability …

Nanoparticle-mediated remodeling of the tumor microenvironment to enhance immunotherapy

S Musetti, L Huang - ACS nano, 2018 - ACS Publications
Nanoscience has long been lauded as a method through which tumor-associated barriers
could be overcome. As successful as cancer immunotherapy has been, limitations …

Chemotherapeutic and targeted drugs-induced immunogenic cell death in cancer models and antitumor therapy: An update review

J Zhai, X Gu, Y Liu, Y Hu, Y Jiang… - Frontiers in …, 2023 - frontiersin.org
As traditional strategies for cancer treatment, some chemotherapy agents, such as
doxorubicin, oxaliplatin, cyclophosphamide, bortezomib, and paclitaxel exert their anti-tumor …

Emerging nano‐/microapproaches for cancer immunotherapy

Y Mi, CT Hagan IV, BG Vincent, AZ Wang - Advanced Science, 2019 - Wiley Online Library
Cancer immunotherapy has achieved remarkable clinical efficacy through recent advances
such as chimeric antigen receptor‐T cell (CAR‐T) therapy, immune checkpoint blockade …