Introduction Although antimicrobials have traditionally been used to treat infections and
improve health outcomes, resistance to commonly used antimicrobials has posed a major …

Sepsis, a dysregulated immune response due to life-threatening organ dysfunction, caused
by drug-resistant pathogens, is a major global health threat contributing to high disease …

Background There is limited data on antibiotic treatment in hospitalized neonates in low-and
middle-income countries (LMICs). We aimed to describe patterns of antibiotic use …

Bacterial infections are a major cause of mortality in preterm babies, yet our understanding
of early-life disease-associated immune dysregulation remains limited. Here, we combine …

Despite a significant decline in deaths in children younger than 5 years globally in the past
three decades, preventable and treatable infectious diseases remain the leading cause of …

Neonatal sepsis is defined as a systemic infection within the first 28 days of life, with early-
onset sepsis (EOS) occurring within the first 72h, although the definition of EOS varies in …

Sepsis remains a significant cause of neonatal morbidity and mortality in China. A better
understanding of neonatal sepsis in China as compared with other industrialized and non …

Background Antimicrobial resistance (AMR) has emerged as a global threat to healthcare
resulting in an increase in morbidity and mortality. Neonatal sepsis is ranked as the third …

Neonatal sepsis causes significant global morbidity and mortality, with the highest burden in
resource-limited settings where 99% of neonatal deaths occur. There are multiple …

Objective To provide national-level antibiotic use data from Chinese neonatal intensive care
units to inform future antimicrobial stewardship using a large contemporary cohort of preterm …