Management of hepatocellular carcinoma: a review

ZJ Brown, DI Tsilimigras, SM Ruff, A Mohseni… - JAMA …, 2023 - jamanetwork.com
Importance Hepatocellular carcinoma (HCC) is the sixth most common malignancy and
fourth leading cause of cancer-related death worldwide. Recent advances in systemic and …

Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy

AG Singal, F Kanwal, JM Llovet - Nature reviews Clinical oncology, 2023 - nature.com
Hepatocellular carcinoma (HCC) mortality rates are increasing globally, and particularly in
the Western world. Cirrhosis remains the predominant risk factor for HCC. However …

Current therapies and new developments in NASH

JF Dufour, QM Anstee, E Bugianesi, S Harrison… - Gut, 2022 - gut.bmj.com
Non-alcoholic steatohepatitis is becoming the most important aetiology for advanced liver
disease. There has been important progress in the field in recent years and the complexity of …

Association of bariatric surgery with cancer risk and mortality in adults with obesity

A Aminian, R Wilson, A Al-Kurd, C Tu, A Milinovich… - Jama, 2022 - jamanetwork.com
Importance Obesity increases the incidence and mortality from some types of cancer, but it
remains uncertain whether intentional weight loss can decrease this risk. Objective To …

[HTML][HTML] NAFLD‐related hepatocellular carcinoma: The growing challenge

PA Shah, R Patil, SA Harrison - Hepatology, 2023 - journals.lww.com
Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and
morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the …

Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease

N Fujiwara, N Kubota, E Crouchet, B Koneru… - Science translational …, 2022 - science.org
Prediction of hepatocellular carcinoma (HCC) risk is an urgent unmet need in patients with
nonalcoholic fatty liver disease (NAFLD). In cohorts of 409 patients with NAFLD from …

[HTML][HTML] Systematic review and meta-analysis of the impact of bariatric surgery on future cancer risk

RB Wilson, D Lathigara, D Kaushal - International journal of molecular …, 2023 - mdpi.com
The study aimed to perform a systematic review and meta-analysis of the evidence for the
prevention of future cancers following bariatric surgery. A systematic literature search of the …

[HTML][HTML] Pathogenesis and treatment of non-alcoholic steatohepatitis and its fibrosis

KC Lee, PS Wu, HC Lin - Clinical and molecular hepatology, 2023 - ncbi.nlm.nih.gov
The initial presentation of non-alcoholic steatohepatitis (NASH) is hepatic steatosis. The
dysfunction of lipid metabolism within hepatocytes caused by genetic factors, diet, and …

Nonalcoholic fatty liver disease and hepatocellular carcinoma: Insights in epidemiology, pathogenesis, imaging, prevention and therapy

SA Polyzos, L Chrysavgis, ID Vachliotis… - Seminars in cancer …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is estimated to be the third leading cause of cancer-related
mortality and is characterized by low survival rates. Nonalcoholic fatty liver disease (NAFLD) …

[HTML][HTML] Body fatness associations with cancer: evidence from recent epidemiological studies and future directions

SC Larsson, N Spyrou, CS Mantzoros - Metabolism, 2022 - Elsevier
This narrative review highlights current evidence linking greater body fatness to risk of
various cancers, with focus on evidence from recent large cohort studies and pooled …