Brain‐derived neurotrophic factor and the development of structural neuronal connectivity

S Cohen‐Cory, AH Kidane, NJ Shirkey… - Developmental …, 2010 - Wiley Online Library
During development, neural networks are established in a highly organized manner, which
persists throughout life. Neurotrophins play crucial roles in the developing nervous system …

Development and critical period plasticity of the barrel cortex

RS Erzurumlu, P Gaspar - European Journal of Neuroscience, 2012 - Wiley Online Library
In primary sensory neocortical areas of mammals, the distribution of sensory receptors is
mapped with topographic precision and amplification in proportion to the peripheral receptor …

Cellular and molecular mechanisms regulating neuronal growth by brain‐derived neurotrophic factor

A Gonzalez, G Moya‐Alvarado… - …, 2016 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) and its receptors TrkB and p75 regulate dendritic
and axonal growth during development and maintenance of the mature nervous system; …

Critical period plasticity is disrupted in the barrel cortex of FMR1 knockout mice

EG Harlow, SM Till, TA Russell, LS Wijetunge, P Kind… - Neuron, 2010 - cell.com
Alterations in sensory processing constitute prominent symptoms of fragile X syndrome;
however, little is known about how disrupted synaptic and circuit development in sensory …

The role of neurotrophins during early development

P Bernd - Gene expression, 2018 - pmc.ncbi.nlm.nih.gov
The effects of neurotrophins during the middle and late stages of development are well
known. It was previously thought that neurotrophins had no role during early development …

Genetics of stroke recovery: BDNF val66met polymorphism in stroke recovery and its interaction with aging

M Balkaya, S Cho - Neurobiology of disease, 2019 - Elsevier
Stroke leads to long term sensory, motor and cognitive impairments. Most patients
experience some degree of spontaneous recovery which is mostly incomplete and varying …

Perinatal fentanyl exposure leads to long-lasting impairments in somatosensory circuit function and behavior

JB Alipio, C Haga, ME Fox, K Arakawa… - Journal of …, 2021 - Soc Neuroscience
One consequence of the opioid epidemic are lasting neurodevelopmental sequelae
afflicting adolescents exposed to opioids in the womb. A translationally relevant and …

Engineered BDNF producing cells as a potential treatment for neurologic disease

P Deng, JD Anderson, AS Yu, G Annett… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Brain-derived neurotrophic factor (BDNF) has been implicated in wide range of
neurological diseases and injury. This neurotrophic factor is vital for neuronal health …

Cognitive deficits in Rett syndrome: what we know and what we need to know to treat them

J Berger-Sweeney - Neurobiology of learning and memory, 2011 - Elsevier
Rett syndrome is an autism spectrum disorder and a leading cause of severe mental
retardation in girls. The nature of the cognitive abnormalities in Rett, as described in humans …

What can we get from 'barrels': the rodent barrel cortex as a model for studying the establishment of neural circuits

CS Wu, CJ Ballester Rosado… - European Journal of …, 2011 - Wiley Online Library
Sensory inputs triggered by external stimuli are projected into discrete arrays of neuronal
modules in the primary sensory cortex. This whisker‐to‐barrel pathway has gained in …