Recent advances and new strategies in Leishmaniasis diagnosis

RCF De Brito, RDO Aguiar-Soares… - Applied Microbiology …, 2020 - Springer
Leishmaniasis is a set of complex and multifaceted syndromes, with different clinical
manifestations, caused by different species of the genus Leishmania spp. that can be …

Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis

MC Duarte, DP Lage, VT Martins… - Revista da Sociedade …, 2016 - SciELO Brasil
Visceral leishmaniasis (VL) is one of the most important tropical diseases worldwide.
Although chemotherapy has been widely used to treat this disease, problems related to the …

Immunoinformatics-aided design of a potential multi-epitope peptide vaccine against Leishmania infantum

B Vakili, M Eslami, GR Hatam, B Zare, N Erfani… - International journal of …, 2018 - Elsevier
Visceral leishmaniasis (VL) or kala-azar, the most severe form of the disease, is endemic in
more than eighty countries across the world. To date, there is no approved vaccine against …

A candidate vaccine for human visceral leishmaniasis based on a specific T cell epitope-containing chimeric protein protects mice against Leishmania infantum …

DP Lage, PAF Ribeiro, DS Dias, DVC Mendonça… - npj Vaccines, 2020 - nature.com
Leishmaniases are neglected diseases caused by infection with Leishmania parasites and
there are currently no prophylactic vaccines. In this study, we designed in silico a synthetic …

A TLR9-adjuvanted vaccine formulated into dissolvable microneedle patches or cationic liposomes protects against leishmaniasis after skin or subcutaneous …

JS Lanza, S Vucen, O Flynn, A Donadei… - International Journal of …, 2020 - Elsevier
Re-emergence and geographic expansion of leishmaniasis is accelerating efforts to develop
a safe and effective Leshmania vaccine. Vaccines using Leishmania recombinant antigens …

Antigenicity and Protective Efficacy of a Leishmania Amastigote-specific Protein, Member of the Super-oxygenase Family, against Visceral Leishmaniasis

VT Martins, MA Chavez-Fumagalli… - PLoS neglected …, 2013 - journals.plos.org
Background The present study aimed to evaluate a hypothetical Leishmania amastigote-
specific protein (LiHyp1), previously identified by an immunoproteomic approach performed …

A spotlight on the diagnostic methods of a fatal disease Visceral Leishmaniasis

A Kumar, SC Pandey, M Samant - Parasite immunology, 2020 - Wiley Online Library
Leishmania donovani (a causative agent of visceral leishmaniasis) poses a serious health
threat to the human population which is fatal if left untreated. The life cycle of Leishmania …

Mimotope-Based Vaccines of Leishmania infantum Antigens and Their Protective Efficacy against Visceral Leishmaniasis

LE Costa, LR Goulart, NCJ Pereira, MIS Lima… - PloS one, 2014 - journals.plos.org
Background The development of cost-effective prophylactic strategies to prevent
leishmaniasis has become a high-priority. The present study has used the phage display …

Nanomedicine in leishmaniasis: A promising tool for diagnosis, treatment and prevention of disease-An update overview

JP Assolini, ACM Carloto, BT da Silva Bortoleti… - European Journal of …, 2022 - Elsevier
Leishmaniasis is a neglected tropical disease that has a wide spectrum of clinical
manifestations, ranging from visceral to cutaneous, with millions of new cases and …

Recombinant prohibitin protein of Leishmania infantum acts as a vaccine candidate and diagnostic marker against visceral leishmaniasis

DS Dias, PAF Ribeiro, VT Martins, DP Lage… - Cellular …, 2018 - Elsevier
Visceral leishmaniasis (VL) represents a serious public health problem, as Leishmania
infantum is one of main disease causative agents in the Americas. In a previous …