Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases
S Ji, M Xiong, H Chen, Y Liu, L Zhou, Y Hong… - … and Targeted Therapy, 2023 - nature.com
The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …
Fetoplacental vasculature as a model to study human cardiovascular endocrine disruption
Increasing evidence has associated the exposure of endocrine-disrupting chemicals (EDCs)
with the cardiovascular (CV) system. This exposure is particularly problematic in a sensitive …
with the cardiovascular (CV) system. This exposure is particularly problematic in a sensitive …
Young exosome bio‐nanoparticles restore aging‐impaired tendon stem/progenitor cell function and reparative capacity
S Jin, Y Wang, X Wu, Z Li, L Zhu, Y Niu… - Advanced …, 2023 - Wiley Online Library
Aging impairs tendon stem/progenitor cell function and tendon homeostasis, however,
effective treatments for aging‐induced tendon diseases are lacking. Exosomes are naturally …
effective treatments for aging‐induced tendon diseases are lacking. Exosomes are naturally …
Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations
Y Wang, P Deng, Y Liu, Y Wu, Y Chen, Y Guo… - Nature …, 2020 - nature.com
Age-related osteoporosis is characterized by the deterioration in bone volume and strength,
partly due to the dysfunction of bone marrow mesenchymal stromal/stem cells (MSCs) …
partly due to the dysfunction of bone marrow mesenchymal stromal/stem cells (MSCs) …
[HTML][HTML] Aging Process and Related Diseases
The aging process is a complex biological phenomenon that results in the gradual decline of
physiological function and an increased risk of age-related diseases. While aging is a …
physiological function and an increased risk of age-related diseases. While aging is a …
MicroRNAs expression profiles in cardiovascular diseases
E Bronze-da-Rocha - BioMed research international, 2014 - Wiley Online Library
The current search for new markers of cardiovascular diseases (CVDs) is explained by the
high morbidity and mortality still observed in developed and developing countries due to …
high morbidity and mortality still observed in developed and developing countries due to …
Dynamic DNA methylation during aging: a “prophet” of age-related outcomes
FH Xiao, HT Wang, QP Kong - Frontiers in genetics, 2019 - frontiersin.org
The biological markers of aging used to predict physical health status in older people are of
great interest. Telomere shortening, which occurs during the process of cell replication, was …
great interest. Telomere shortening, which occurs during the process of cell replication, was …
[HTML][HTML] Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging
I Grammatikakis, AC Panda, K Abdelmohsen… - Aging (Albany …, 2014 - ncbi.nlm.nih.gov
During aging, progressive deleterious changes increase the risk of disease and death.
Prominent molecular hallmarks of aging are genomic instability, telomere attrition …
Prominent molecular hallmarks of aging are genomic instability, telomere attrition …
Cellular senescence and tumor promotion: Is aging the key?
N Loaiza, M Demaria - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2016 - Elsevier
The senescence response is a potent tumor suppressor mechanism characterized by an
irreversible growth arrest in response to potentially oncogenic signals to prevent the …
irreversible growth arrest in response to potentially oncogenic signals to prevent the …
Towards a unified mechanistic theory of aging
G Barja - Experimental gerontology, 2019 - Elsevier
A large amount of the longevity-modulating genes discovered during the last two decades
are highly conserved during evolution from yeast and invertebrates to mammals. Many …
are highly conserved during evolution from yeast and invertebrates to mammals. Many …