Ca2+ dynamics in interstitial cells: foundational mechanisms for the motor patterns in the gastrointestinal tract

KM Sanders, BT Drumm, CA Cobine… - Physiological …, 2024 - journals.physiology.org
The gastrointestinal (GI) tract displays multiple motor patterns that move nutrients and
wastes through the body. Smooth muscle cells (SMCs) provide the forces necessary for GI …

Sex neurosteroids: Hormones made by the brain for the brain

L Fester, GM Rune - Neuroscience Letters, 2021 - Elsevier
In general, hippocampal neurons are capable of synthesizing sex steroids de novo from
cholesterol, since the brain is equipped with all the enzymes required for the synthesis of …

Cholesterol‐promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus

L Fester, L Zhou, A Bütow, C Huber… - …, 2009 - Wiley Online Library
Cholesterol of glial origin promotes synaptogenesis (Mauch et al.,(2001) Science 294: 1354–
1357). Because in the hippocampus local estradiol synthesis is essential for …

Interstitial cells of Cajal (ICC) and gastrointestinal stromal tumor (GIST): facts, speculations, and myths

KW Min, M Leabu - Journal of cellular and molecular medicine, 2006 - Wiley Online Library
Interstitial cells of Cajal (ICC) is a peculiar cell network composed of cells having processes
described by the eminent Spanish neuroanatomist of the 19th century, S. Ramon y Cajal …

Depletion of membrane cholesterol eliminates the Ca2+‐activated component of outward potassium current and decreases membrane capacitance in rat uterine …

A Shmygol, K Noble, S Wray - The Journal of physiology, 2007 - Wiley Online Library
Changes in membrane cholesterol content have potent effects on cell signalling and
contractility in rat myometrium and other smooth muscles. We have previously shown that …

Estrogen synthesis in the hippocampus

L Fester, J Prange-Kiel, H Jarry, GM Rune - Cell and tissue research, 2011 - Springer
Estradiol plays essential roles in the modulation of synaptic plasticity and neuroprotection in
males as well as in females, as has been shown particularly in the hippocampus. Although it …

Large conductance, calcium-and voltage-gated potassium (BK) channels: regulation by cholesterol

AM Dopico, AN Bukiya, AK Singh - Pharmacology & therapeutics, 2012 - Elsevier
Cholesterol (CLR) is an essential component of eukaryotic plasma membranes. CLR
regulates the membrane physical state, microdomain formation and the activity of membrane …

Caveolae and calcium handling, a review and a hypothesis

EE Daniel, A El‐Yazbi, WJ Cho - Journal of cellular and …, 2006 - Wiley Online Library
Caveolae are associated with molecules crucial for calcium handling. This review considers
the roles of caveolae in calcium handling for smooth muscle and interstitial cells of Cajal …

Proteins of interstitial cells of Cajal and intestinal smooth muscle, colocalized with caveolin-1

WJ Cho, EE Daniel - American Journal of Physiology …, 2005 - journals.physiology.org
The murine jejunum and lower esophageal sphincter (LES) were examined to determine the
locations of various signaling molecules and their colocalization with caveolin-1 and one …

Matrix metalloproteinase‐2, caveolins, focal adhesion kinase and c‐Kit in cells of the mouse myocardium

WJ Cho, AK Chow, R Schulz… - Journal of Cellular and …, 2007 - Wiley Online Library
Abstract Matrix metalloproteinase‐2 (MMP‐2) may play roles at intracellular and
extracellular sites of the heart in ischaemia/reperfusion injury. Caveolins (Cav‐1,‐2 and‐3) …