[HTML][HTML] Cross-linking mass spectrometry (XL-MS): An emerging technology for interactomics and structural biology
Protein-protein interactions are fundamental to the formation of intricate interaction networks
and the assembly of multisubunit protein complexes that represent the functional …
and the assembly of multisubunit protein complexes that represent the functional …
Sharing the SAGA
D Helmlinger, L Tora - Trends in biochemical sciences, 2017 - cell.com
Transcription initiation is a major regulatory step in eukaryotic gene expression. Co-
activators establish transcriptionally competent promoter architectures and chromatin …
activators establish transcriptionally competent promoter architectures and chromatin …
[HTML][HTML] Wheat microbiome bacteria can reduce virulence of a plant pathogenic fungus by altering histone acetylation
Interactions between bacteria and fungi have great environmental, medical, and agricultural
importance, but the molecular mechanisms are largely unknown. Here, we study the …
importance, but the molecular mechanisms are largely unknown. Here, we study the …
[PDF][PDF] SAGA is a general cofactor for RNA polymerase II transcription
T Baptista, S Grünberg, N Minoungou, MJE Koster… - Molecular cell, 2017 - cell.com
Prior studies suggested that SAGA and TFIID are alternative factors that promote RNA
polymerase II transcription, with about 10% of genes in S. cerevisiae dependent on SAGA …
polymerase II transcription, with about 10% of genes in S. cerevisiae dependent on SAGA …
[PDF][PDF] Transcription of nearly all yeast RNA polymerase II-transcribed genes is dependent on transcription factor TFIID
L Warfield, S Ramachandran, T Baptista, D Devys… - Molecular cell, 2017 - cell.com
Previous studies suggested that expression of most yeast mRNAs is dominated by either
transcription factor TFIID or SAGA. We re-examined the role of TFIID by rapid depletion of S …
transcription factor TFIID or SAGA. We re-examined the role of TFIID by rapid depletion of S …
Structure of SAGA and mechanism of TBP deposition on gene promoters
G Papai, A Frechard, O Kolesnikova, C Crucifix… - Nature, 2020 - nature.com
Abstract SAGA (Spt–Ada–Gcn5–acetyltransferase) is a 19-subunit complex that stimulates
transcription via two chromatin-modifying enzymatic modules and by delivering the TATA …
transcription via two chromatin-modifying enzymatic modules and by delivering the TATA …
Two roles for the yeast transcription coactivator SAGA and a set of genes redundantly regulated by TFIID and SAGA
Deletions within genes coding for subunits of the transcription coactivator SAGA caused
strong genome-wide defects in transcription and SAGA-mediated chromatin modifications. In …
strong genome-wide defects in transcription and SAGA-mediated chromatin modifications. In …
[HTML][HTML] Structure of the human SAGA coactivator complex
The SAGA complex is a regulatory hub involved in gene regulation, chromatin modification,
DNA damage repair and signaling. While structures of yeast SAGA (ySAGA) have been …
DNA damage repair and signaling. While structures of yeast SAGA (ySAGA) have been …
The SAGA chromatin-modifying complex: the sum of its parts is greater than the whole
JHM Soffers, JL Workman - Genes & Development, 2020 - genesdev.cshlp.org
There are many large protein complexes involved in transcription in a chromatin context.
However, recent studies on the SAGA coactivator complex are generating new paradigms …
However, recent studies on the SAGA coactivator complex are generating new paradigms …
Inhibition of histone acetyltransferase GCN5 by a transcription factor FgPacC controls fungal adaption to host-derived iron stress
Q Gu, Y Wang, X Zhao, B Yuan, M Zhang… - Nucleic Acids …, 2022 - academic.oup.com
Poaceae plants can locally accumulate iron to suppress pathogen infection. It remains
unknown how pathogens overcome host-derived iron stress during their successful …
unknown how pathogens overcome host-derived iron stress during their successful …