Cancer is one of the leading causes of death. Globally a huge number of deaths and new
incidences are reported annually. Heterocyclic compounds have been proved to be very …

Quinazoline is a heterocyclic compound having biological activities. It is aromatic in nature
having bicyclic structure containing benzene ring and pyrimidine ring. Quinazoline and its …

Dual targeting by a single molecule has emerged as a promising strategy for fighting cancer.
In this study, a new set of 2-thioquinazolin-4 (3H)-ones as potential anti-cancer surrogates …

The cysteine proteases, cruzain and Tbr CATL (rhodesain), are therapeutic targets for
Chagas disease and Human African Trypanosomiasis, respectively. Among the known …

Malaria has been a major parasitic disease in tropical and subtropical regions and is
estimated to kill between one and two million people (mainly children) every year. Novel anti …

Emerging resistance to current antimalarials is reducing their effectiveness and therefore
there is a need to develop new antimalarial therapies. Toward this goal, high throughput …

To contribute to the global effort to develop new antimalarial therapies, we previously
disclosed initial findings on the optimization of the dihydroquinazolinone-3-carboxamide …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

Humans have lived in tenuous battle with malaria over millennia. Today, while much of the
world is free of the disease, areas of South America, Asia, and Africa still wage this war with …

There is an urgent need to populate the antimalarial clinical portfolio with new candidates
because of resistance against frontline antimalarials. To discover new antimalarial …