A new in vivo model to test anti-tuberculosis drugs using fluorescence imaging

A Zelmer, P Carroll, N Andreu, K Hagens… - Journal of …, 2012 - academic.oup.com
Objectives The current method for testing new drugs against tuberculosis in vivo is the
enumeration of bacteria in organs by cfu assay. Owing to the slow growth rate of …

[HTML][HTML] Acid stress response of a mycobacterial proteome: insight from a gene ontology analysis

BAP Roxas, Q Li - International journal of clinical and experimental …, 2009 - ncbi.nlm.nih.gov
Acidity in vesicles of macrophages is a general signal that bacteria respond to during
infection. Mycobacteria are particularly capable of resisting the acidification in macrophages …

Tuberculosis: Experimental Models, Innovations, and Challenges

SS Jhamb, RP Singh, PP Singh - Recent Advances in Pharmaceutical …, 2023 - Springer
Tuberculosis (TB) is among the top ten killer diseases and remains the number one cause of
death due to infection. A major bottleneck in TB research remains the availability of suitable …