Biology and biomechanics of the heart valve extracellular matrix
KM Kodigepalli, K Thatcher, T West… - Journal of …, 2020 - mdpi.com
Heart valves are dynamic structures that, in the average human, open and close over
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …
100,000 times per day, and 3× 109 times per lifetime to maintain unidirectional blood flow …
On the simulation of mitral valve function in health, disease, and treatment
The mitral valve (MV) is the left atrioventricular heart valve that regulates blood flow between
the left atrium and left ventricle (LV) during the cardiac cycle. Contrary to the aortic valve …
the left atrium and left ventricle (LV) during the cardiac cycle. Contrary to the aortic valve …
Integration of polarized spatial frequency domain imaging (pSFDI) with a biaxial mechanical testing system for quantification of load-dependent collagen architecture …
Collagen fiber networks provide the structural strength of tissues, such as tendons, skin and
arteries. Quantifying the fiber architecture in response to mechanical loads is essential …
arteries. Quantifying the fiber architecture in response to mechanical loads is essential …
Simulating the time evolving geometry, mechanical properties, and fibrous structure of bioprosthetic heart valve leaflets under cyclic loading
Currently, the most common replacement heart valve design is the 'bioprosthetic'heart valve
(BHV), which has important advantages in that it does not require permanent anti …
(BHV), which has important advantages in that it does not require permanent anti …
Sinoatrial node structure, mechanics, electrophysiology and the chronotropic response to stretch in rabbit and mouse
EA MacDonald, J Madl, J Greiner, AF Ramadan… - Frontiers in …, 2020 - frontiersin.org
The rhythmic electrical activity of the heart's natural pacemaker, the sinoatrial node (SAN),
determines cardiac beating rate (BR). SAN electrical activity is tightly controlled by multiple …
determines cardiac beating rate (BR). SAN electrical activity is tightly controlled by multiple …
A noninvasive method for the determination of in vivo mitral valve leaflet strains
Assessment of mitral valve (MV) function is important in many diagnostic, prognostic, and
surgical planning applications for treatment of MV disease. Yet, to date, there are no …
surgical planning applications for treatment of MV disease. Yet, to date, there are no …
Pre-surgical Prediction of Ischemic Mitral Regurgitation Recurrence Using In Vivo Mitral Valve Leaflet Strains
Ischemic mitral regurgitation (IMR) is a prevalent cardiac disease associated with substantial
morbidity and mortality. Contemporary surgical treatments continue to have limited long-term …
morbidity and mortality. Contemporary surgical treatments continue to have limited long-term …
Development of a functionally equivalent model of the mitral valve chordae tendineae through topology optimization
Ischemic mitral regurgitation (IMR) is a currently prevalent disease in the US that is projected
to become increasingly common as the aging population grows. In recent years, image …
to become increasingly common as the aging population grows. In recent years, image …
Regulation of valve interstitial cell homeostasis by mechanical deformation: implications for heart valve disease and surgical repair
Mechanical stress is one of the major aetiological factors underlying soft-tissue remodelling,
especially for the mitral valve (MV). It has been hypothesized that altered MV tissue stress …
especially for the mitral valve (MV). It has been hypothesized that altered MV tissue stress …
Computational analysis of heart valve growth and remodeling after the Ross procedure
E Middendorp, F Braeu, F Baaijens… - … and modeling in …, 2024 - Springer
During the Ross procedure, an aortic heart valve is replaced by a patient's own pulmonary
valve. The pulmonary autograft subsequently undergoes substantial growth and remodeling …
valve. The pulmonary autograft subsequently undergoes substantial growth and remodeling …