Various internal and external factors negatively affect the homeostatic equilibrium of
organisms at the molecular to the whole-body level, inducing the so-called state of stress …

Maternal and paternal factors influence offspring development and program its genome for
successful postnatal life. Based on the stressors during gestation, the pregnant female …

Placental trophoblasts form the interface between the fetal and maternal environments and
serve to limit the maternal–fetal spread of viruses. Here we show that cultured primary …

Metformin is everywhere. Originally introduced in clinical practice as an antidiabetic agent,
its role as a therapeutic agent is expanding to include treatment of prediabetes mellitus …

The concept of 'lifestyle 'includes different factors such as nutrition, behavior, stress, physical
activity, working habits, smoking and alcohol consumption. Increasing evidence shows that …

There are known sex specific differences in fetal and neonatal morbidity and mortality. There
are also known differences in birthweight centile with males generally being larger than …

Background Circulating nucleic acids (CNAs) offer unique opportunities for early diagnosis
of clinical conditions. Here we show that microRNAs, a family of small non-coding regulatory …

The placenta is a transient organ that forms during pregnancy to support the growth and
development of the fetus. During human placental development, trophoblast cells …

Background: The discovery of circulating fetal nucleic acids in maternal plasma has opened
up new possibilities for noninvasive prenatal diagnosis. MicroRNAs (miRNAs), a class of …

Preeclampsia (PE) is a complex disorder that is characterized by hypertension and
proteinuria after the 20th week of pregnancy, and it causes most neonatal morbidity and …