Ovarian cancer (OC) is one of the most common gynecologic tumors worldwide and one
with the highest mortality. Cisplatin (DDP) is the first platinum-based complex approved by …

Chemoresistance and metastasis are the major challenges for the current ovarian cancer
treatment. Understanding the mechanisms of ovarian cancer progression and metastasis is …

Background Liver metastasis (LM) is a major obstacle to the prognosis of gastric cancer
(GC) patients, but the molecular mechanism underlying gastric cancer liver metastasis (GC …

The metastatic organotropism has been one of the cancer's greatest mysteries since the
'seed and soil'hypothesis. Although the role of EGFR in cancer cells is well studied, the …

Abstract Cisplatin (cis-diammine-dichloro-platinum II) was initially discovered to prevent the
growth of Escherichia coli and was further recognized for its anti-neoplastic and cytotoxic …

Extracellular vesicles (EVs) including exosomes, microvesicles, oncosomes, and
microparticles have been associated with communicating anti-cancer drug-resistance. The …

The approval of the first small interfering RNA (siRNA) drug Patisiran by FDA in 2018 marks
a new era of RNA interference (RNAi) therapeutics. MicroRNAs (miRNA), an important post …

Exosomes are a class of extracellular vesicles ranging in size from 40 to 100 nm, which are
secreted by both cancer cells and multiple stromal cells in the tumor microenvironment …

Chemotherapy, one of the principal approaches for cancer patients, plays a crucial role in
controlling tumor progression. Clinically, tumors reveal a satisfactory response following the …

Precision medicine and personalized medicine are based on the development of
biomarkers, and liquid biopsy has been reported to be able to detect biomarkers that carry …