Nowadays, orthodontic treatment has become increasingly popular. However, the biological
mechanisms of orthodontic tooth movement (OTM) have not been fully elucidated. We were …

During tissue healing, the dynamic and temporal alterations required for effective repair
occur in the structure and composition of the extracellular matrix (ECM). Matricellular …

Wnt–β-catenin signaling plays a key role in orthodontic tooth movement (OTM), a common
clinical practice for malocclusion correction. However, its targeted periodontal ligament …

The goal of periodontal regenerative therapy is to predictably restore the tooth's supporting
periodontal tissues and form a new connective tissue attachment of periodontal ligament …

Sclerostin (Scl) negatively regulates bone formation and favors bone resorption. Osteocytes,
the cells responsible for mechanosensing, are known as the primary source of Scl and are a …

Matricellular proteins (MCPs) are defined as extracellular matrix (ECM) associated proteins
that are important regulators and integrators of microenvironmental signals, contributing to …

During orthodontic tooth movement (OTM), the periodontal ligament (PDL) plays a crucial
role in regulating the tissue remodeling process. To decipher the cellular and molecular …

Periodontal ligament (PDL), as a mechanical connection between the alveolar bone and
tooth, plays a pivotal role in force-induced orthodontic tooth movement (OTM). However …

Several studies have demonstrated that exosomes (Exos) are involved in the regulation of
macrophage polarization and osteoclast differentiation. However, the characteristics as well …

Tooth movement is a biological process of bone remodeling induced by mechanical force.
Sclerostin secreted by osteocytes is mechanosensory and important in bone remodeling …