Theory of protein folding: the energy landscape perspective
JN Onuchic, Z Luthey-Schulten… - Annual review of …, 1997 - annualreviews.org
▪ Abstract The energy landscape theory of protein folding is a statistical description of a
protein's potential surface. It assumes that folding occurs through organizing an ensemble of …
protein's potential surface. It assumes that folding occurs through organizing an ensemble of …
Inverse statistical physics of protein sequences: a key issues review
In the course of evolution, proteins undergo important changes in their amino acid
sequences, while their three-dimensional folded structure and their biological function …
sequences, while their three-dimensional folded structure and their biological function …
Protein 3D structure computed from evolutionary sequence variation
The evolutionary trajectory of a protein through sequence space is constrained by its
function. Collections of sequence homologs record the outcomes of millions of evolutionary …
function. Collections of sequence homologs record the outcomes of millions of evolutionary …
Funnels, pathways, and the energy landscape of protein folding: a synthesis
JD Bryngelson, JN Onuchic, ND Socci… - Proteins: Structure …, 1995 - Wiley Online Library
The understanding, and even the description of protein folding is impeded by the complexity
of the process. Much of this complexity can be described and understood by taking a …
of the process. Much of this complexity can be described and understood by taking a …
A field guide to foldamers
The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …
The pairwise energy content estimated from amino acid composition discriminates between folded and intrinsically unstructured proteins
The structural stability of a protein requires a large number of interresidue interactions. The
energetic contribution of these can be approximated by low-resolution force fields extracted …
energetic contribution of these can be approximated by low-resolution force fields extracted …
Principles of protein folding—a perspective from simple exact models
General principles of protein structure, stability, and folding kinetics have recently been
explored in computer simulations of simple exact lattice models. These models represent …
explored in computer simulations of simple exact lattice models. These models represent …
Molten globule and protein folding
OB Ptitsyn - Advances in protein chemistry, 1995 - Elsevier
Publisher Summary This chapter describes the present state of the studies of the molten
globule state and its role in protein folding and physiological processes. Recent data on the …
globule state and its role in protein folding and physiological processes. Recent data on the …
Design principles of 3D epigenetic memory systems
Cells remember their identities, in part, by using epigenetic marks—chemical modifications
placed along the genome. How can mark patterns remain stable over cell generations …
placed along the genome. How can mark patterns remain stable over cell generations …
Effective energy functions for protein structure prediction
T Lazaridis, M Karplus - Current opinion in structural biology, 2000 - Elsevier
Protein structure prediction, fold recognition, homology modeling and design rely mainly on
statistical effective energy functions. Although the theoretical foundation of such functions is …
statistical effective energy functions. Although the theoretical foundation of such functions is …