BRD4, the most extensively studied member of the BET family, is an epigenetic regulator
that localizes to DNA via binding to acetylated histones and controls the expression of …

As epigenetic readers of the histone code, BRD4 is the most extensively and thoroughly
studied member of BET family, which plays a critical role in many human diseases including …

The bromodomain and extra-terminal domain (BET) family of proteins are readers which
specifically recognize histone-acetylated lysine residues. Each BET bromodomain protein …

Neuropathic pain (NP) is an intolerable pain syndrome that arises from continuous
inflammation and excitability after nerve injury. Only a few NP therapeutics are currently …

Therapy for multiple myeloma (MM), a hematologic neoplasm of plasma cells, has
undergone remarkable changes over the past 25 years. Small molecules (molecular weight …

Epigenetics is defined as the stable and heritable alternations in gene expression without
changing the DNA nucleotide sequence. The initiation and progression of cancer result from …

Seven-membered heterocyclic compounds are important drug scaffolds because of their
unique chemical structures. They widely exist in natural products and show a variety of …

Sepsis has long been a major health problem worldwide. It threatens the lives of
hospitalized patients and has been one of the leading causes of death in hospitalized …

Multiple myeloma (MM) is a genetically complex disease. Identification of mutations and
aberrant signaling pathways that contribute to the progression of MM and drug resistance …

Drugs not only perturb their immediate protein targets but also modulate multiple signaling
pathways. In this study, we explored networks modulated by several drugs across multiple …