Pulmonary arterial hypertension (PAH) is a disease resulting in increased right ventricular
(RV) afterload and RV remodeling. PAH results in altered RV structure and function at …

The use of replacement heart valves continues to grow due to the increased prevalence of
valvular heart disease resulting from an ageing population. Since bioprosthetic heart valves …

Background Pulmonary hypertension (PH) results in increased right ventricular (RV)
afterload and ventricular remodeling. Sacubitril/valsartan (sac/val) is a dual acting drug …

Computational implementation of physical and physiologically realistic constitutive models is
critical for numerical simulation of soft biological tissues in a variety of biomedical …

Right ventricular (RV) failure in response to pulmonary hypertension (PH) is a severe
disease that remains poorly understood. PH-induced pressure overload leads to changes in …

Tissue growth and remodeling (G&R) is often central to disease etiology and progression, so
understanding G&R is essential for understanding disease and developing effective …

The function of right ventricle (RV) is recognized to play a key role in the development of
many cardiopulmonary disorders, such as pulmonary arterial hypertension (PAH). Given the …

Fundamental to developing a deeper understanding of pathophysiological remodeling in
mitral valve (MV) disease is the development of an accurate tissue-level constitutive model …

Purpose: Collagen is the main load-bearing component of the eye, and collagen crimp is a
critical determinant of tissue mechanical behavior. We test the hypothesis that collagen …

Our goal was to quantify and characterize how the collagen fiber crimp waviness of the
lamina cribrosa (LC) and peripapillary sclera (PPS) changes with intraocular pressure (IOP) …