[HTML][HTML] Glioma-associated microglia/macrophages (GAMs) in glioblastoma: Immune function in the tumor microenvironment and implications for immunotherapy
C Lin, N Wang, C Xu - Frontiers in Immunology, 2023 - frontiersin.org
Glioma is a mixed solid tumor composed of neoplastic and non-neoplastic components.
Glioma-associated macrophages and microglia (GAMs) are crucial elements of the glioma …
Glioma-associated macrophages and microglia (GAMs) are crucial elements of the glioma …
[HTML][HTML] The diversity and dynamics of tumor-associated macrophages in recurrent glioblastoma
Despite tremendous efforts to exploit effective therapeutic strategies, most glioblastoma
(GBM) inevitably relapse and become resistant to therapies, including radiotherapy and …
(GBM) inevitably relapse and become resistant to therapies, including radiotherapy and …
Harmonized single-cell landscape, intercellular crosstalk and tumor architecture of glioblastoma
SUMMARY Glioblastoma, isocitrate dehydrogenase (IDH)-wildtype (hereafter, GB), is an
aggressive brain malignancy associated with a dismal prognosis and poor quality of life …
aggressive brain malignancy associated with a dismal prognosis and poor quality of life …
[HTML][HTML] Sestrin2 provides cerebral protection through activation of Nrf2 signaling in microglia following subarachnoid hemorrhage
Y Yang, H Ding, C Yang, J Wu, Y Bao, S Lan… - Frontiers in …, 2023 - frontiersin.org
Subarachnoid hemorrhage (SAH) is a neurological emergency characterized by
dysfunctional inflammatory response. However, no effective therapeutic options have been …
dysfunctional inflammatory response. However, no effective therapeutic options have been …
[HTML][HTML] Single-cell RNA sequencing reveals changes in glioma-associated macrophage polarization and cellular states of malignant gliomas with high AQP4 …
R Wang, L Peng, Y Xiao, Q Zhou, Z Wang, L Tang… - Cancer gene …, 2023 - nature.com
Glioma is the most common primary central nervous system tumor in adults. Aquaporin-4, as
a water channel protein encoded by AQP4 in the brain, is reported to alter its aggregation …
a water channel protein encoded by AQP4 in the brain, is reported to alter its aggregation …
[HTML][HTML] Single-Cell Transcriptomics Reveals the Heterogeneity of the Immune Landscape of IDH–Wild-Type High-Grade Gliomas
X Ran, J Zheng, L Chen, Z Xia, Y Wang, C Sun… - Cancer Immunology …, 2024 - AACR
Abstract Isocitrate dehydrogenase (IDH)–wild-type (WT) high-grade gliomas, especially
glioblastomas, are highly aggressive and have an immunosuppressive tumor …
glioblastomas, are highly aggressive and have an immunosuppressive tumor …
[HTML][HTML] The importance of M1-and M2-polarized macrophages in glioma and as potential treatment targets
J Ren, B Xu, J Ren, Z Liu, L Cai, X Zhang, W Wang… - Brain Sciences, 2023 - mdpi.com
Glioma is the most common and malignant tumor of the central nervous system.
Glioblastoma (GBM) is the most aggressive glioma, with a poor prognosis and no effective …
Glioblastoma (GBM) is the most aggressive glioma, with a poor prognosis and no effective …
[HTML][HTML] Identification of genes with oscillatory expression in glioblastoma: the paradigm of SOX2
Quiescence, a reversible state of cell-cycle arrest, is an important state during both normal
development and cancer progression. For example, in glioblastoma (GBM) quiescent …
development and cancer progression. For example, in glioblastoma (GBM) quiescent …
Advanced insights on tumor-associated macrophages revealed by single-cell RNA sequencing: The intratumor heterogeneity, functional phenotypes, and cellular …
S Yang, M Wang, Y Hua, J Li, H Zheng, M Cui… - Cancer Letters, 2024 - Elsevier
Single-cell RNA sequencing (scRNA-seq) is an emerging technology used for cellular
transcriptome analysis. The application of scRNA-seq has led to profoundly advanced …
transcriptome analysis. The application of scRNA-seq has led to profoundly advanced …
[HTML][HTML] Integration analysis of single-cell and spatial transcriptomics reveal the cellular heterogeneity landscape in glioblastoma and establish a polygenic risk model
Y Liu, Z Wu, Y Feng, J Gao, B Wang, C Lian… - Frontiers in …, 2023 - frontiersin.org
Background Glioblastoma (GBM) is adults' most common and fatally malignant brain tumor.
The heterogeneity is the leading cause of treatment failure. However, the relationship …
The heterogeneity is the leading cause of treatment failure. However, the relationship …