Resistance to rifampicin (RIF) is a broad subject covering not just the mechanism of clinical
resistance, nearly always due to a genetic change in the β subunit of bacterial RNA …

Genome sequencing of Streptomyces, myxobacteria, and fungi showed that although each
strain contains genes that encode the enzymes to synthesize a plethora of potential …

Unlocking the rich harvest of marine microbial ecosystems has the potential to both
safeguard the existence of our species for the future, while also presenting significant …

Covering up to end 2015 Microbial fermentation provides an attractive alternative to
chemical synthesis for the production of structurally complex natural products. In most cases …

Natural products discovery from actinomycetes has been on the decline in recent years, and
has suffered from a lack of innovative ways to discover new secondary metabolites within a …

We show that selection of drug-resistant bacterial mutants allows the discovery of
antibacterial compounds. Mutant strains of a soil-isolated Streptomyces species that does …

The emergence of drug-resistant pathogens poses a major threat to public health. Although
influenced by multiple factors, high-level resistance is often associated with mutations in …

With the increase in antimicrobial resistance and the subsequent demand for novel
therapeutics, the deep-sea fish microbiome can be a relatively untapped source of …

Microorganisms are a major source of new therapeutics. However, the discovery and
sustainable production of these compounds are often hampered owing to limited access to …

As bacteria and fungi have been found to contain genes encoding enzymes that synthesize
a plethora of potential secondary metabolites, interest has grown in the activation of these …