Treatment‐resistant major depressive disorder: Canadian expert consensus on definition and assessment

YE Rybak, KSP Lai, R Ramasubbu… - Depression and …, 2021 - Wiley Online Library
Background Treatment‐resistant depression (TRD) is a debilitating chronic mental illness
that confers increased morbidity and mortality, decreases the quality of life, impairs …

Immune cell composition in unipolar depression: a comprehensive systematic review and meta-analysis

NV Sørensen, BH Frandsen, S Orlovska-Waast… - Molecular …, 2023 - nature.com
Depression has been associated with inflammatory pathophysiological mechanisms,
including alterations in amount of circulating immune cells. However, no meta-analysis …

[HTML][HTML] Economic impact of treatment-resistant depression: a retrospective observational study

V Pérez-Sola, M Roca, J Alonso, A Gabilondo… - Journal of Affective …, 2021 - Elsevier
Background To determine the incidence of Treatment-Resistant Depression (TRD) in Spain
and to estimate its economic burden, using real world data. Methods A retrospective …

Risk factors for suicide and suicide attempts among patients with treatment-resistant depression: nested case-control study

J Reutfors, TML Andersson, A Tanskanen… - Archives of suicide …, 2021 - Taylor & Francis
The risk of suicide is elevated among patients with treatment-resistant depression (TRD).
Risk factors for suicide and suicide attempts among cases and controls with TRD were …

Exome-wide association study of treatment-resistant depression suggests novel treatment targets

SB Shah, TN Peddada, C Song, M Mensah, H Sung… - Scientific Reports, 2023 - nature.com
Abstract Treatment-resistant depression (TRD) is a severe form of major depressive disorder
(MDD) with substantial public health impact and poor treatment outcome. Treatment …

[HTML][HTML] Predictors and risk factors of treatment-resistant depression: A systematic review

SJ O'Connor, N Hewitt, J Kuc… - The Journal of Clinical …, 2023 - psychiatrist.com
Objective: To systematically review the literature to identify and categorize the predictors and
risk factors for treatment-resistant depression (TRD). Data Sources: Online databases …

Clinical characteristics of treatment-resistant depression in adults in Hungary: Real-world evidence from a 7-year-long retrospective data analysis

P Döme, P Kunovszki, P Takacs, L Feher, T Balazs… - PLoS …, 2021 - journals.plos.org
Purpose Treatment-resistant depression (TRD) is associated with a poor quality of life and
high economic burden. This observational retrospective epidemiological study aimed to …

[HTML][HTML] Courses of treatment and risk factors for treatment-resistant depression in Finnish primary and special healthcare: a nationwide cohort study

M Lähteenvuo, H Taipale, A Tanskanen… - Journal of Affective …, 2022 - Elsevier
Objective Investigate incidence, risk factors and courses of treatment for treatment-resistant
depression (TRD) in primary and special healthcare. Methods All patients identified from …

Treatment-resistant depression and risk of all-cause mortality and suicidality in Danish patients with major depression

FH Gronemann, MB Jørgensen, M Nordentoft… - Journal of psychiatric …, 2021 - Elsevier
Objective Treatment-resistant depression (TRD) has been associated with higher mortality
and risk of suicide, but this has mainly been showed in few studies which did not include self …

[HTML][HTML] Treatment patterns in patients with treatment-resistant depression in Danish patients with major depressive disorder

FH Gronemann, J Petersen, S Alulis, KJ Jensen… - Journal of Affective …, 2021 - Elsevier
Objective: To describe treatment patterns in patients with treatment-resistant depression
(TRD) and major depressive disorder (MDD) stratified by depression severity and year of …