Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease

JM Pickard, MY Zeng, R Caruso… - Immunological …, 2017 - Wiley Online Library
The intestinal tract of mammals is colonized by a large number of microorganisms including
trillions of bacteria that are referred to collectively as the gut microbiota. These indigenous …

[HTML][HTML] Iron in infection and immunity

M Nairz, G Weiss - Molecular Aspects of Medicine, 2020 - Elsevier
Iron is an essential micronutrient for virtually all living cells. In infectious diseases, both
invading pathogens and mammalian cells including those of the immune system require iron …

Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome

A Vich Vila, F Imhann, V Collij… - Science translational …, 2018 - science.org
Changes in the gut microbiota have been associated with two of the most common
gastrointestinal diseases, inflammatory bowel disease (IBD) and irritable bowel syndrome …

The effect of host genetics on the gut microbiome

MJ Bonder, A Kurilshikov, EF Tigchelaar, Z Mujagic… - Nature …, 2016 - nature.com
The gut microbiome is affected by multiple factors, including genetics. In this study, we
assessed the influence of host genetics on microbial species, pathways and gene ontology …

[HTML][HTML] Mechanisms of inflammation-driven bacterial dysbiosis in the gut

MY Zeng, N Inohara, G Nuñez - Mucosal immunology, 2017 - Elsevier
The gut microbiota has diverse and essential roles in host metabolism, development of the
immune system and as resistance to pathogen colonization. Perturbations of the gut …

Microbiota metabolites in health and disease

JL McCarville, GY Chen, VD Cuevas… - Annual review of …, 2020 - annualreviews.org
Metabolism is one of the strongest drivers of interkingdom interactions—including those
between microorganisms and their multicellular hosts. Traditionally thought to fuel energy …

Host genetics and gut microbiome: challenges and perspectives

A Kurilshikov, C Wijmenga, J Fu, A Zhernakova - Trends in immunology, 2017 - cell.com
The mammalian gut is colonized by trillions of microorganisms collectively called the
microbiome. It is increasingly clear that this microbiome has a critical role of in many aspects …

Siderophores in iron metabolism: from mechanism to therapy potential

BR Wilson, AR Bogdan, M Miyazawa… - Trends in molecular …, 2016 - cell.com
Iron is an essential nutrient for life. During infection, a fierce battle of iron acquisition occurs
between the host and bacterial pathogens. Bacteria acquire iron by secreting siderophores …

The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy

M Lindefeldt, A Eng, H Darban, A Bjerkner… - npj Biofilms and …, 2019 - nature.com
The gut microbiota has been linked to various neurological disorders via the gut–brain axis.
Diet influences the composition of the gut microbiota. The ketogenic diet (KD) is a high-fat …

Determinants of IBD heritability: genes, bugs, and more

W Turpin, A Goethel, L Bedrani… - Inflammatory bowel …, 2018 - academic.oup.com
Defining the etiology of inflammatory bowel disease (IBD) continues to elude researchers, in
part due to the possibility that there may be different triggers for a spectrum of disease …