Although advances in intensive care have enabled more patients to survive an acute critical
illness, they also have created a large and growing population of chronically critically ill …

Background This is an update of a review last published in Issue 5, 2010, of The Cochrane
Library. Reducing weaning time is desirable in minimizing potential complications from …

Heart Failure Society (JHFS). The working committee for this project includes members and
collaborators involved in the previous versions of the heart failure guidelines and members …

Importance Although most critically ill patients receive invasive mechanical ventilation (IMV),
few studies have characterized how IMV is discontinued in practice. Objective To describe …

Objective: Postextubation distress after a successful spontaneous breathing trial is
associated with increased morbidity and mortality. Predicting postextubation distress is …

Background Approaches to removal of sedation and mechanical ventilation for critically ill
patients vary widely. Our aim was to assess a protocol that paired spontaneous awakening …

ContextGoal-directed delivery of sedative and analgesic medications is recommended as
standard care in intensive care units (ICUs) because of the impact these medications have …

Background Predictive indexes of weaning from mechanical ventilation are often inaccurate.
Among the many indexes used in clinical practice, the rapid shallow breathing index is one …

Context Tracheotomy is used to replace endotracheal intubation in patients requiring
prolonged ventilation; however, there is considerable variability in the time considered …

Background The need for reintubation after extubation and discontinuation of mechanical
ventilation is not uncommon and is associated with increased mortality. Noninvasive positive …