Environmental perturbations are encountered by microorganisms regularly and will require
metabolic adaptations to ensure an organism can survive in the newly presenting …

Metabolism is a dynamic network of biochemical reactions that support systemic
homeostasis amidst changing nutritional, environmental, and physical activity factors. The …

Comprehensive whole-body models (WBMs) accounting for organ-specific dynamics have
been developed to simulate adult metabolism, but such models do not exist for infants. Here …

Dynamic flux balance analysis (dFBA) models are very popular in systems biology because
of the many possible applications. dFBA consists of dynamic mass balance equations that …

Insulin, a peptide hormone secreted by pancreatic β cells, affects the development of
diabetes and associated complications. Herein, we propose an electrochemical aptasensor …

Metabolic diseases (MD) are amenable to network-based modeling frameworks, given the
systemic perturbations induced by disrupted molecular mechanisms. We present here a …

Dynamical models in the form of systems of ordinary differential equations have become a
standard tool in systems biology. Many parameters of such models are usually unknown and …

A whole-body model is a computational representation of sex-specific and organ-resolved
whole-body metabolism. In this issue of Cell Metabolism, Zaunseder et al. report whole-body …

As metabolomics datasets are becoming larger and more complex, there is an increasing
need for model-based data integration and analysis to optimally leverage these data …

Motivation Mitochondria are essential for cellular metabolism and are inherently flexible to
allow correct function in a wide range of tissues. Consequently, dysregulated mitochondrial …