Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-
renewal potentials. MSCs-based therapies have been widely utilized for the treatment of …

The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …

The osteoblast/osteoclast and M1/M2 macrophage ratios play critical roles in delayed
fracture healing. Robust osteoblast differentiation and M2 macrophage polarization can …

Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …

To solve the issue of unsatisfactory recruitment of mesenchymal stem cells (MSCs) around
implant in osteoporotic fractures, we fabricated a ROS-responsive system on titanium …

Fibronectin (FN) functions as a potent stimulator of osteogenic differentiation, and bone
fracture healing. In FN family, FN1 acts as an interactive protein gene product to mediate …

Articular cartilage repair and regeneration is an unmet clinical need because of the poor self-
regeneration capacity of the tissue. In this study, we found that the expression of …

Although bone tissue has the ability to heal itself, beyond a certain point, bone defects
cannot rebuild themselves, and the challenge is how to promote bone tissue regeneration …

The principal purpose of tissue engineering is to stimulate the injured or unhealthy tissues to
revive their primary function through the simultaneous use of chemical agents, cells, and …

Background: Implantation of bone marrow mesenchymal stem cells (BMSCs) is a potential
alternative for promoting bone defects healing or osseointegration in osteoporosis …