Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …

Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …

Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …

The current research paradigm for Huntington's disease is based on participants with overt
clinical phenotypes and does not address its pathophysiology nor the biomarker changes …

Glutamate is the primary excitatory neurotransmitter of the brain. Cellular homeostasis of
glutamate is of paramount importance for normal brain function and relies on an intricate …

Huntington's disease is the most frequent autosomal dominant neurodegenerative disorder;
however, no disease-modifying interventions are available for patients with this disease. The …

Parkinson disease (PD) is the most common neurodegenerative movement disorder. In
Europe, prevalence and incidence rates for PD are estimated at approximately 108–257/100 …

Huntington disease (HD) is a neurodegenerative disease caused by CAG repeat expansion
in the huntingtin gene (HTT) and involves a complex web of pathogenic mechanisms …

Ageing is the primary risk factor for most neurodegenerative diseases, including Alzheimer
disease (AD) and Parkinson disease (PD). One in ten individuals aged≥ 65 years has AD …

Ferroptosis is a type of cell death that was described less than a decade ago. It is caused by
the excess of free intracellular iron that leads to lipid (hydro) peroxidation. Iron is essential …