Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …

Accurate DNA repair and replication are critical for genomic stability and cancer prevention.
RAD51 and its gene family are key regulators of DNA fidelity through diverse roles in double …

Homologous recombination (HR) serves to eliminate deleterious lesions, such as double-
stranded breaks and interstrand crosslinks, from chromosomes. HR is also critical for the …

Mutation of the breast cancer susceptibility gene, BRCA2, leads to breast and ovarian
cancers. Mechanistic insight into the functions of human BRCA2 has been limited by the …

The BRCA2 tumour suppressor protein preserves genomic integrity via interactions with the
DNA-strand exchange RAD51 protein in homology-directed repair. The RAD51-binding TR2 …

Inherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers.
Their ubiquitously expressed protein products are implicated in processes fundamental to all …

Breast cancer progression involves multiple genetic events, which can activate dominant-
acting oncogenes and disrupt the function of specific tumor suppressor genes. This article …

Germline mutations in BRCA1 confer a high risk of breast and ovarian tumors. The role of
BRCA1 in tumor suppression is not yet understood, but both transcription and repair …

Inheritance of one defective BRCA2 allele predisposes humans to breast cancer. To
establish a mouse model for BRCA2-associated breast cancer, we generated mouse …

Germline mutations in BRCA1 and BRCA2 predispose to common human malignancies,
most notably tumors of the breast and ovaries. The proteins encoded by these genes have …