A long-held goal in sequencing has been to use a voltage-biased nanoscale pore in a
membrane to measure the passage of a linear, single-stranded (ss) DNA or RNA molecule …

Nanopores in thin membranes play important roles in science and industry. Single
nanopores have provided a step-change in portable DNA sequencing and understanding …

Solid-state nanopores are nm sized apertures formed in thin synthetic membranes. These
single molecule sensors have been used in a variety of biophysical and diagnostic …

Biological nanopores are nanoscale sensors employed for high-throughput, low-cost, and
long read-length DNA sequencing applications. The analysis and sequencing of proteins …

The electrical current blockade of a peptide or protein threading through a nanopore can be
used as a fingerprint of the molecule in biosensor applications. However, threading of full …

Much more than ever, nucleic acids are recognized as key building blocks in many of lifeʼs
processes, and the science of studying these molecular wonders at the single-molecule …

A nanopore-based device provides single-molecule detection and analytical capabilities
that are achieved by electrophoretically driving molecules in solution through a nano-scale …

Small RNA molecules have an important role in gene regulation and RNA silencing therapy,
but it is challenging to detect these molecules without the use of time-consuming radioactive …

Synthetic nanopores have been used to study individual biomolecules in high throughput,
but their performance as sensors does not match that of biological ion channels. Challenges …

The passage of individual molecules through nanosized pores in membranes is central to
many processes in biology. Previously, experiments have been restricted to naturally …