Induction of long-term synaptic potentiation (LTP) in excitatory neurons triggers a transient
enlargement of dendritic spines followed by decay to sustained size expansion, a process …

ABSTRACT Globular (G)-actin, the actin monomer, assembles into polarized filaments that
form networks that can provide structural support, generate force and organize the cell …

Cells have many types of actin structures, which must assemble from a common monomer
pool. Yet, it remains poorly understood how monomers are distributed to and shared …

Dendritic spines are major sites of excitatory synaptic connection in pyramidal neurons of
the forebrain, and their functional regulation underlies the development of functional …

PPP-family phosphatases such as PP1 have little intrinsic specificity. Cofactors can target
PP1 to substrates or subcellular locations, but it remains unclear how they might confer …

Dendrites are the input compartment of the neuron, receiving and integrating incoming
information. Dendritic trees are often highly complex and branched. Their branch extension …

Neurons of the CNS elaborate highly branched dendritic arbors that host numerous dendritic
spines, which serve as the postsynaptic platform for most excitatory synapses. The actin …

Phosphoinositides (PIs) play important roles in the structure and function of the brain.
Associations between PIs and the pathophysiology of schizophrenia have been studied …

Many adult neurons are dynamically remodeled across timescales ranging from the rapid
addition and removal of specific synaptic connections, to largescale structural plasticity …

Dendritic spines constitute the major compartments of excitatory post-synapses. They
undergo activity-dependent enlargement, which is thought to increase the synaptic efficacy …