Humans, like all mammals, partition their daily behaviour into activity (wakefulness) and rest
(sleep) phases that differ largely in their metabolic requirements. The circadian clock …

Abstract Circadian (∼ 24-hour) timing systems pervade all kingdoms of life and temporally
optimize behavior and physiology in humans. Relatively recent changes to our …

Circadian rhythms, metabolism, and nutrition are intimately linked [1, 2], although effects of
meal timing on the human circadian system are poorly understood. We investigated the …

The molecular circadian clock regulates metabolic processes within the cell, and the
alignment of these clocks between tissues is essential for the maintenance of metabolic …

Caloric restriction (CR) extends lifespan in mammals, yet the mechanisms underlying its
beneficial effects remain unknown. The manner in which CR has been implemented in …

Natriuretic peptides are a family of three structurally related hormone/paracrine factors. Atrial
natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are secreted from the cardiac …

The circadian system orchestrates the temporal organization of many aspects of physiology,
including metabolism, in synchrony with the 24 hr rotation of the Earth. Like the metabolic …

Obesity has become a serious public health problem and a major risk factor for the
development of illnesses, such as insulin resistance and hypertension. Human homeostatic …

Daily rhythms in physiological and behavioral processes are controlled by a network of
circadian clocks, reset by inputs and delivering circadian signals to the brain and peripheral …

The classic theories of aging such as the free radical theory, including its mitochondria‐
related versions, have largely focused on a few specific processes of senescence …