[HTML][HTML] Metazoan micrornas
DP Bartel - Cell, 2018 - cell.com
MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …
[HTML][HTML] How to plumb a pisces: understanding vascular development and disease using zebrafish embryos
BM Hogan, S Schulte-Merker - Developmental cell, 2017 - cell.com
Our vasculature plays diverse and critical roles in homeostasis and disease. In recent
decades, the use of zebrafish has driven our understanding of vascular development into …
decades, the use of zebrafish has driven our understanding of vascular development into …
Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium
JJ Ghersi, G Baldissera, J Hintzen, SA Luff… - Nature Cell …, 2023 - nature.com
Definitive haematopoietic stem and progenitor cells (HSPCs) generate erythroid, lymphoid
and myeloid lineages. HSPCs are produced in the embryo via transdifferentiation of …
and myeloid lineages. HSPCs are produced in the embryo via transdifferentiation of …
A framework for understanding the roles of miRNAs in animal development
C Alberti, L Cochella - Development, 2017 - journals.biologists.com
MicroRNAs (miRNAs) contribute to the progressive changes in gene expression that occur
during development. The combined loss of all miRNAs results in embryonic lethality in all …
during development. The combined loss of all miRNAs results in embryonic lethality in all …
Cell-type-specific profiling of loaded miRNAs from Caenorhabditis elegans reveals spatial and temporal flexibility in Argonaute loading
CA Brosnan, AJ Palmer, S Zuryn - Nature communications, 2021 - nature.com
Multicellularity has coincided with the evolution of microRNAs (miRNAs), small regulatory
RNAs that are integrated into cellular differentiation and homeostatic gene-regulatory …
RNAs that are integrated into cellular differentiation and homeostatic gene-regulatory …
PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans
Intracranial aneurysm (IA) rupture leads to subarachnoid hemorrhage, a sudden-onset
disease that often causes death or severe disability. Although genome-wide association …
disease that often causes death or severe disability. Although genome-wide association …
MicroRNA-223 suppresses the canonical NF-κB pathway in basal keratinocytes to dampen neutrophilic inflammation
MicroRNA-223 is known as a myeloid-enriched anti-inflammatory microRNA that is
dysregulated in numerous inflammatory conditions. Here, we report that neutrophilic …
dysregulated in numerous inflammatory conditions. Here, we report that neutrophilic …
[HTML][HTML] Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction
Emerging evidence indicates that angiopoietin-2 (Angpt2), a well-recognized vascular
destabilizing factor, is a biomarker of poor outcome in ischemic heart disease. However, its …
destabilizing factor, is a biomarker of poor outcome in ischemic heart disease. However, its …
The developmental-genetics of canalization
Canalization, or robustness to genetic or environmental perturbations, is fundamental to
complex organisms. While there is strong evidence for canalization as an evolved property …
complex organisms. While there is strong evidence for canalization as an evolved property …
The role of MicroRNAs in tendon injury, repair, and related tissue engineering
Tendon injuries are one of the most common musculoskeletal disorders that cause
considerable morbidity and significantly compromise the patients' quality of life. The innate …
considerable morbidity and significantly compromise the patients' quality of life. The innate …