The HIV-1 rev protein
VW Pollard, MH Malim - Annual review of microbiology, 1998 - annualreviews.org
▪ Abstract The nuclear export of intron-containing HIV-1 RNA is critically dependent on the
activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles …
activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles …
Human retrovirus genomic RNA packaging
Two non-covalently linked copies of the retrovirus genome are specifically recruited to the
site of virus particle assembly and packaged into released particles. Retroviral RNA …
site of virus particle assembly and packaged into released particles. Retroviral RNA …
The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm.
BE Meyer, MH Malim - Genes & development, 1994 - genesdev.cshlp.org
The HIV-1 Rev protein is a nuclear trans-activator essential for the transport of unspliced
viral transcripts to the cytoplasm. In this paper we demonstrate that Rev, rather than being …
viral transcripts to the cytoplasm. In this paper we demonstrate that Rev, rather than being …
Cofactor requirements for nuclear export of rev response element (RRE)–and constitutive transport element (CTE)–containing retroviral RNAs: an unexpected role for …
W Hofmann, B Reichart, A Ewald, E Müller… - The Journal of cell …, 2001 - rupress.org
Nuclear export of proteins containing leucine-rich nuclear export signals (NESs) is mediated
by the export receptor CRM1/exportin1. However, additional protein factors interacting with …
by the export receptor CRM1/exportin1. However, additional protein factors interacting with …
Inhibition of HIV-1 replication in lymphocytes by mutants of the Rev cofactor eIF-5A
D Bevec, H Jaksche, M Oft, T Wöhl, M Himmelspach… - Science, 1996 - science.org
Eukaryotic initiation factor 5A (eIF-5A) is a cellular cofactor required for the function of the
human immunodeficiency virus type-1 (HIV-1) Rev trans-activator protein. The majority of a …
human immunodeficiency virus type-1 (HIV-1) Rev trans-activator protein. The majority of a …
Evidence that HIV‐1 Rev directly promotes the nuclear export of unspliced RNA.
U Fischer, S Meyer, M Teufel, C Heckel… - The EMBO …, 1994 - embopress.org
The Rev trans‐activator of human immunodeficiency virus type 1 (HIV‐1) is a protein that
regulates the simultaneous appearance in the cytoplasm of both spliced and unspliced …
regulates the simultaneous appearance in the cytoplasm of both spliced and unspliced …
Neomycin− acridine conjugate: a potent inhibitor of rev-rre binding
SR Kirk, NW Luedtke, Y Tor - Journal of the American Chemical …, 2000 - ACS Publications
The successful replication of many retroviruses requires an ordered pattern of viral gene
expression. 1 Small organic molecules that target viral RNA sites and prevent the formation …
expression. 1 Small organic molecules that target viral RNA sites and prevent the formation …
RNA transport
▪ Abstract RNA molecules synthesized in the nucleus are transported to their sites of function
throughout the eukaryotic cell by specific transport pathways. This review focuses on …
throughout the eukaryotic cell by specific transport pathways. This review focuses on …
Costabilization of peptide and RNA structure in an HIV Rev peptide-RRE complex
R Tan, AD Frankel - Biochemistry, 1994 - ACS Publications
Revised Manuscript Received September 30, 1994® abstract: An arginine-rich peptide
corresponding to amino acids 34-50 of the human immunodeficiency virus Rev protein has …
corresponding to amino acids 34-50 of the human immunodeficiency virus Rev protein has …
Real-time kinetics of HIV-1 Rev-Rev response element interactions: Definition of minimal binding sites on RNA and protein and stoichiometric analysis
DI Van Ryk, S Venkatesan - Journal of Biological Chemistry, 1999 - ASBMB
The kinetics of interaction between the human immunodeficiency virus-1 Rev protein and its
RNA target, Rev response element (RRE) RNA was determined in vitro using a biosensor …
RNA target, Rev response element (RRE) RNA was determined in vitro using a biosensor …