Acute respiratory distress syndrome (ARDS) is a common clinical syndrome of acute
respiratory failure as a result of diffuse lung inflammation and oedema. ARDS can be …

Although much progress has been made in ARDS phenotyping, implementation of precision
medicine practices will depend on conducting phenotype-aware trials using rapid point of …

Background The recent emergence of COVID-19, rapid worldwide spread, and incomplete
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …

Background Antimicrobial resistance (AMR) is rising at an alarming rate and complicating
the management of infectious diseases including lower respiratory tract infections (LRTI) …

There are well demonstrated differences in tumor cell metabolism between right sided
(RCC) and left sided (LCC) colon cancer, which could underlie the robust differences …

Dexamethasone is the standard of care for critically ill patients with COVID-19, but the
mechanisms by which it decreases mortality and its immunological effects in this setting are …

Clinical and molecular heterogeneity are common features of human disease.
Understanding the basis for heterogeneity has led to major advances in therapy for many …

Introduction Patients with COVID-19-related acute respiratory distress syndrome (ARDS)
show limited systemic hyperinflammation, but immunomodulatory treatments are effective …

Genomic and proteomic screens have identified numerous host factors of SARS-CoV-2, but
efficient delineation of their molecular roles during infection remains a challenge. Here we …

The utilization of host-cell machinery during SARS-CoV-2 infection can overwhelm the
protein-folding capacity of the endoplasmic reticulum and activate the unfolded protein …