The effects of neutrophil-generated hypochlorous acid and other hypohalous acids on host and pathogens

A Ulfig, LI Leichert - Cellular and Molecular Life Sciences, 2021 - Springer
Neutrophils are predominant immune cells that protect the human body against infections by
deploying sophisticated antimicrobial strategies including phagocytosis of bacteria and …

CRISPR-Cas-mediated transcriptional modulation: The therapeutic promises of CRISPRa and CRISPRi

L Bendixen, TI Jensen, RO Bak - Molecular Therapy, 2023 - cell.com
The CRISPR-Cas system is commonly known for its ability to cleave DNA in a
programmable manner, which has democratized gene editing and facilitated recent …

[HTML][HTML] The roles of peroxiredoxin and thioredoxin in hydrogen peroxide sensing and in signal transduction

LES Netto, F Antunes - Molecules and cells, 2016 - Elsevier
A challenge in the redox field is the elucidation of the molecular mechanisms, by which H 2
O 2 mediates signal transduction in cells. This is relevant since redox pathways are …

The interplay between oxidative stress and bioenergetic failure in neuropsychiatric illnesses: can we explain it and can we treat it?

G Morris, KR Walder, M Berk, W Marx, AJ Walker… - Molecular biology …, 2020 - Springer
Nitro-oxidative stress and lowered antioxidant defences play a key role in neuropsychiatric
disorders such as major depression, bipolar disorder and schizophrenia. The first part of this …

[HTML][HTML] Enhancing glycosylase base-editor activity by fusion to transactivation modules

X Dong, C Yang, Z Ma, M Chen, X Zhang, C Bi - Cell Reports, 2022 - cell.com
Base editors (BEs) are a group of genetic tools with potential in both scientific and medical
research. Recently, a glycosylase BE (GBE), which converts C to G, has been constructed …

Drought and heat stress interactions modify photorespiration and hydrogen peroxide content in silver fir

F Alongi, P Petrík, NK Ruehr - Tree Physiology, 2024 - academic.oup.com
Photorespiration (PR) greatly reduces net carbon assimilation in trees (by c. 25%), but has
received recent attention particular for its potential role in stress-signaling through the …

Mitochondrial function and nutrient sensing pathways in ageing: enhancing longevity through dietary interventions

E Tomtheelnganbee, P Sah, R Sharma - Biogerontology, 2022 - Springer
Ageing is accompanied by alterations in several biochemical processes, highly influenced
by its environment. It is controlled by the interactions at various levels of biological hierarchy …

Protective Effect of Lacticaseibacillus casei CRL 431 Postbiotics on Mitochondrial Function and Oxidative Status in Rats with Aflatoxin B1–Induced Oxidative Stress

I Guerrero-Encinas, JN González-González… - Probiotics and …, 2021 - Springer
Studies have shown that the intracellular content of probiotic (postbiotics) has antioxidant
properties, which can improve the antioxidant status in vivo. However, its absorption and …

[HTML][HTML] NADPH oxidase and mitochondria are relevant sources of superoxide anion in the oxinflammatory response of macrophages exposed to airborne particulate …

L Cáceres, ML Paz, M Garcés, V Calabró… - Ecotoxicology and …, 2020 - Elsevier
Exposure to ambient air particulate matter (PM) is associated with increased
cardiorespiratory morbidity and mortality. In this context, alveolar macrophages exhibit …

Protein kinase A activation alleviates cataract formation via increased gap junction intercellular communication

Y Du, Y Tong, Y Quan, G Wang, H Cheng, S Gu… - Iscience, 2023 - cell.com
Cataract is the leading cause of blindness worldwide. Here, we reported a potential,
effective therapeutic mean for cataract prevention and treatment. Gap junction …