The effects of neutrophil-generated hypochlorous acid and other hypohalous acids on host and pathogens
A Ulfig, LI Leichert - Cellular and Molecular Life Sciences, 2021 - Springer
Neutrophils are predominant immune cells that protect the human body against infections by
deploying sophisticated antimicrobial strategies including phagocytosis of bacteria and …
deploying sophisticated antimicrobial strategies including phagocytosis of bacteria and …
CRISPR-Cas-mediated transcriptional modulation: The therapeutic promises of CRISPRa and CRISPRi
L Bendixen, TI Jensen, RO Bak - Molecular Therapy, 2023 - cell.com
The CRISPR-Cas system is commonly known for its ability to cleave DNA in a
programmable manner, which has democratized gene editing and facilitated recent …
programmable manner, which has democratized gene editing and facilitated recent …
[HTML][HTML] The roles of peroxiredoxin and thioredoxin in hydrogen peroxide sensing and in signal transduction
A challenge in the redox field is the elucidation of the molecular mechanisms, by which H 2
O 2 mediates signal transduction in cells. This is relevant since redox pathways are …
O 2 mediates signal transduction in cells. This is relevant since redox pathways are …
The interplay between oxidative stress and bioenergetic failure in neuropsychiatric illnesses: can we explain it and can we treat it?
Nitro-oxidative stress and lowered antioxidant defences play a key role in neuropsychiatric
disorders such as major depression, bipolar disorder and schizophrenia. The first part of this …
disorders such as major depression, bipolar disorder and schizophrenia. The first part of this …
[HTML][HTML] Enhancing glycosylase base-editor activity by fusion to transactivation modules
X Dong, C Yang, Z Ma, M Chen, X Zhang, C Bi - Cell Reports, 2022 - cell.com
Base editors (BEs) are a group of genetic tools with potential in both scientific and medical
research. Recently, a glycosylase BE (GBE), which converts C to G, has been constructed …
research. Recently, a glycosylase BE (GBE), which converts C to G, has been constructed …
Drought and heat stress interactions modify photorespiration and hydrogen peroxide content in silver fir
Photorespiration (PR) greatly reduces net carbon assimilation in trees (by c. 25%), but has
received recent attention particular for its potential role in stress-signaling through the …
received recent attention particular for its potential role in stress-signaling through the …
Mitochondrial function and nutrient sensing pathways in ageing: enhancing longevity through dietary interventions
E Tomtheelnganbee, P Sah, R Sharma - Biogerontology, 2022 - Springer
Ageing is accompanied by alterations in several biochemical processes, highly influenced
by its environment. It is controlled by the interactions at various levels of biological hierarchy …
by its environment. It is controlled by the interactions at various levels of biological hierarchy …
Protective Effect of Lacticaseibacillus casei CRL 431 Postbiotics on Mitochondrial Function and Oxidative Status in Rats with Aflatoxin B1–Induced Oxidative Stress
I Guerrero-Encinas, JN González-González… - Probiotics and …, 2021 - Springer
Studies have shown that the intracellular content of probiotic (postbiotics) has antioxidant
properties, which can improve the antioxidant status in vivo. However, its absorption and …
properties, which can improve the antioxidant status in vivo. However, its absorption and …
[HTML][HTML] NADPH oxidase and mitochondria are relevant sources of superoxide anion in the oxinflammatory response of macrophages exposed to airborne particulate …
Exposure to ambient air particulate matter (PM) is associated with increased
cardiorespiratory morbidity and mortality. In this context, alveolar macrophages exhibit …
cardiorespiratory morbidity and mortality. In this context, alveolar macrophages exhibit …
Protein kinase A activation alleviates cataract formation via increased gap junction intercellular communication
Y Du, Y Tong, Y Quan, G Wang, H Cheng, S Gu… - Iscience, 2023 - cell.com
Cataract is the leading cause of blindness worldwide. Here, we reported a potential,
effective therapeutic mean for cataract prevention and treatment. Gap junction …
effective therapeutic mean for cataract prevention and treatment. Gap junction …