The COVID-19 vaccine race: challenges and opportunities in vaccine formulation

J Wang, Y Peng, H Xu, Z Cui, RO Williams - Aaps Pharmscitech, 2020 - Springer
In the race for a safe and effective vaccine against coronavirus disease (COVID)-19,
pharmaceutical formulation science plays a critical role throughout the development …

Effect of linker length and residues on the structure and stability of a fusion protein with malaria vaccine application

S Shamriz, H Ofoghi, N Moazami - Computers in Biology and Medicine, 2016 - Elsevier
Background Recombinant protein technology has revolutionized the world of biology and
medicine. Following this progress, fusion protein technology, as a novel innovation, has …

Development of chimeric peptides to facilitate the neutralisation of lipopolysaccharides during bactericidal targeting of multidrug-resistant Escherichia coli

Z Wang, X Liu, D Teng, R Mao, Y Hao, N Yang… - Communications …, 2020 - nature.com
Pathogenic Escherichia coli can cause fatal diarrheal diseases in both animals and humans.
However, no antibiotics or antimicrobial peptides (AMPs) can adequately kill resistant …

Molecular docking studies of bioactive compounds from Annona muricata Linn as potential inhibitors for Bcl-2, Bcl-w and Mcl-1 antiapoptotic proteins

MN Mohamad Rosdi, S Mohd Arif, MH Abu Bakar… - Apoptosis, 2018 - Springer
Annona muricata Linn or usually identified as soursop is a potential anticancer plant that has
been widely reported to contain valuable chemopreventive agents known as annonaceous …

Structure Based in Silico Screening Revealed a Potent Acinetobacter Baumannii Ftsz Inhibitor From Asinex Antibacterial Library

A Navid, S Ahmad, R Sajjad, S Raza… - … /ACM Transactions on …, 2021 - ieeexplore.ieee.org
The superbug Acinetobacter baumannii is an increasingly prevalent pathogen of the
intensive care units where its treatment is challenging. The identification of newer drug …

In Silico Drug Design of Thiolactomycin Derivatives Against Mtb-KasA Enzyme to Inhibit Multidrug Resistance of Mycobacterium tuberculosis

DR Durairaj, P Shanmughavel - Interdisciplinary Sciences: Computational …, 2019 - Springer
Tuberculosis (TB) is a leading infectious disease which kills a huge number of people every
year over a decade, caused by Mycobacterium tuberculosis. The conventional drugs in the …

Peptide sequence-driven direct electron transfer properties and binding behaviors of gold-binding peptide-fused glucose dehydrogenase on electrode

H Lee, EM Lee, SS Reginald, IS Chang - Iscience, 2021 - cell.com
Oriented enzyme immobilization on electrodes is crucial for interfacial electrical coupling of
direct electron transfer (DET)-based enzyme-electrode systems. As inorganic-binding …

Production of recombinant HIV-1 p24-Nef protein in two forms as potential candidate vaccines in three vehicles

MS Larijani, MH Pouriayevali, SM Sadat… - Current drug …, 2020 - ingentaconnect.com
Background: Different approaches have been investigated to develop a preventive or
therapeutic vaccine, although none of them has been fully practical. Therapeutic vaccines …

Structural insights into betaine aldehyde dehydrogenase (BADH2) from Oryza sativa explored by modeling and simulations

A Baicharoen, R Vijayan, P Pongprayoon - Scientific reports, 2018 - nature.com
Abstract Betaine aldehyde dehydrogenase 2 (BADH2) plays a key role in the accumulation
of 2-acetyl-1-pyrroline (2AP), a fragrant compound in rice (Oryza sativa). BADH2 catalyses …

Engineering the chloroplast of Chlamydomonas reinhardtii to express the recombinant PfCelTOS-Il2 antigen-adjuvant fusion protein

S Shamriz, H Ofoghi - Journal of biotechnology, 2018 - Elsevier
Malaria is an infectious disease having a large negative impact on economic growth.
Vaccines are considered as a novel strategy to reduce the burden of malaria. Malaria …