[HTML][HTML] The biology of aging and cancer: a brief overview of shared and divergent molecular hallmarks

JR Aunan, WC Cho, K Søreide - Aging and disease, 2017 - ncbi.nlm.nih.gov
Aging is the inevitable time-dependent decline in physiological organ function and is a
major risk factor for cancer development. Due to advances in health care, hygiene control …

Systemic lupus erythematosus in children and young people

A Charras, E Smith, CM Hedrich - Current rheumatology reports, 2021 - Springer
Abstract Purpose of Review Juvenile-onset systemic lupus erythematosus ((j) SLE) is an
autoimmune/inflammatory disease that results in significant damage and disability. When …

The microRNA regulatory landscape of MSC-derived exosomes: a systems view

SW Ferguson, J Wang, CJ Lee, M Liu… - Scientific reports, 2018 - nature.com
Mesenchymal stem cell (MSC)-derived exosomes mediate tissue regeneration in a variety of
diseases including ischemic heart injury, liver fibrosis, and cerebrovascular disease. Despite …

The role of epigenetics in autoimmune/inflammatory disease

AEA Surace, CM Hedrich - Frontiers in immunology, 2019 - frontiersin.org
Historically, systemic self-inflammatory conditions were classified as either autoinflammatory
and caused by the innate immune system or autoimmune and driven by adaptive immune …

Bovine milk-derived exosomes as a drug delivery vehicle for miRNA-based therapy

L del Pozo-Acebo, MC López de las Hazas… - International journal of …, 2021 - mdpi.com
MicroRNAs (miRNAs) are small non-coding RNAs with a known role as mediators of gene
expression in crucial biological processes, which converts them into high potential …

Human long noncoding RNA interactome: detection, characterization and function

M Kazimierczyk, MK Kasprowicz, ME Kasprzyk… - International journal of …, 2020 - mdpi.com
The application of a new generation of sequencing techniques has revealed that most of the
genome has already been transcribed. However, only a small part of the genome codes …

MicroRNA regulatory networks in human adipose tissue and obesity

P Arner, A Kulyté - Nature Reviews Endocrinology, 2015 - nature.com
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression and,
therefore, biological processes in different tissues. A major function of miRNAs in adipose …

Molecular and biological hallmarks of ageing

JR Aunan, MM Watson, HR Hagland… - Journal of British …, 2016 - academic.oup.com
Background Ageing is the inevitable time-dependent decline in physiological organ function
that eventually leads to death. Age is a major risk factor for many of the most common …

MicroRNAs: roles in regulating neuroinflammation

AD Gaudet, LK Fonken, LR Watkins… - The …, 2018 - journals.sagepub.com
MicroRNAs (miRNAs) are small noncoding RNAs that broadly affect cellular and
physiological function in all multicellular organisms. Here, the role of miRNAs in …

PolymiRTS Database 3.0: linking polymorphisms in microRNAs and their target sites with human diseases and biological pathways

A Bhattacharya, JD Ziebarth, Y Cui - Nucleic acids research, 2014 - academic.oup.com
Poly morphisms in mi cro R NAs (miRNAs) and their t arget s ites (PolymiRTS) are known to
disrupt miRNA function, leading to the development of disease and variation in physiological …