As an essential innate immune population for maintaining body homeostasis and warding
off foreign pathogens, macrophages display high plasticity and perform diverse supportive …

Neutrophils are the most abundant leukocytes in blood and are considered to be the first line
of defense during inflammation and infections. In addition, neutrophils are also found …

Cancer cells can evade immune surveillance through the expression of inhibitory ligands
that bind their cognate receptors on immune effector cells. Expression of programmed death …

Neutrophils play an important role in cancer. This does not only relate to the well‐
established prognostic value of the presence of neutrophils, either in the blood or in tumor …

Antibody therapy of cancer is increasingly used in the clinic and has improved patient's life
expectancy. Except for immune checkpoint inhibition, the mode of action of many antibodies …

Therapeutic monoclonal antibodies (mAb), directed toward either tumor antigens or
inhibitory checkpoints on immune cells, are effective in cancer therapy. Increasing evidence …

In the past three decades, a great interest has arisen in the use of immunoglobulins as
therapeutic agents. In particular, since the approval of the first monoclonal antibody …

Most clinically used anticancer mAbs are of the IgG isotype, which can eliminate tumor cells
through NK cell–mediated antibody-dependent cellular cytotoxicity and macrophage …

Background Despite the success of immune checkpoint inhibitors against PD-L1 in the
clinic, only a fraction of patients benefit from such therapy. A theoretical strategy to increase …

The advent of immunotherapy has had a major impact on the outcome and overall survival
in many types of cancer. Current immunotherapeutic strategies typically aim to (re) activate …