Feeding and growth are two closely related and important physiological processes in living
organisms. Studies in mammals have provided us with a series of characterizations of …

The interest for developing antibody‐driven therapeutic interventions has exponentially
grown over the last few decades. Even though there have been promising leaps in the …

The genesis of cell-penetrating peptide research (CPP; also known as prote/peptide
transduction domains, PTD, or Trojan peptides) was born from the publication of two parallel …

Background Aggregation of the amyloid-β (Aβ) peptide in the brain is one of the key
pathological events in Alzheimer's disease (AD). Reducing Aβ levels in the brain by …

Background Mass spectrometry (MS)-based cerebrospinal fluid (CSF) proteomics is an
important method for discovering biomarkers of neurodegenerative diseases. CSF serves as …

Background γ-aminobutyric acid (GABA), known as the main inhibitory neurotransmitter in
the brain, exerts immunomodulatory functions by interaction with immune cells, including T …

Filter-aided sample preparation (FASP) is widely used in bottom-up proteomics for tryptic
digestion. However, the sample recovery yield of this method is limited by the amount of the …

The presence of the blood–brain barrier (BBB) creates a nigh-on impenetrable obstacle for
large macromolecular therapeutics that need to be delivered to the brain milieu to treat …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus
disease (COVID-19), has been devastated by COVID-19 in an increasing number of …

Amyloid-β (Aβ) oligomers and protofibrils are suggested to be the most neurotoxic Aβ
species in Alzheimer's disease (AD). Hence, antibodies with strong and selective binding to …