Many proteins require different structural states or conformations for function, and
intrinsically disordered proteins, ie proteins without stable three-dimensional structure, are …

Type III secretion system (T3SS) effectors are key virulence factors that underpin the
infection strategy of many clinically important Gram-negative pathogens, including …

Salmonella injects over 40 virulence factors, termed effectors, into host cells to subvert
diverse host cellular processes. Of these 40 Salmonella effectors, at least 25 have been …

Proteases are powerful enzymes, which cleave peptide bonds, leading most of the time to
irreversible fragmentation or degradation of their substrates. Therefore they control many …

Salmonella is an important zoonotic bacterial species and hazardous for the health of
human beings and livestock globally. Depending on the host, Salmonella can cause …

While differences in human virulence have been reported across nontyphoidal Salmonella
(NTS) serovars and associated subtypes, a rational and scalable approach to identify …

Intracellular bacteria have developed a multitude of mechanisms to influence the post-
translational modifications (PTMs) of host proteins to pathogen advantages. The recent …

Salmonella outer protein D (SopD) is secreted into a host during the first stages of the
Salmonella infection and contributes to the systemic virulence of the bacterium. SopD2 is a …

By applying dual proteome profiling to Salmonella enterica serovar Typhimurium (S.
Typhimurium) encounters with its epithelial host (here, S. Typhimurium infected human …

In the last several years, there has been a tremendous progress in the understanding of host–
pathogen interactions and the mechanisms by which bacterial pathogens modulate …