Glial cells are an essential component of the nervous system of vertebrates and
invertebrates. In the human brain, glia are as numerous as neurons, yet the importance of …

Abstract Cajal-Retzius cells (CRs) are a transient neuronal type of the developing cerebral
cortex. Over the years, they have been shown or proposed to play important functions in …

Neocortex functioning relies on the formation of complex networks that begin to be
assembled during embryogenesis by highly stereotyped processes of cell migration and …

Tangential migration is a mode of cell movement, which in the developing cerebral cortex, is
defined by displacement parallel to the ventricular surface and orthogonal to the radial glial …

Astroglia are a major cell type in the brain and play a key role in many aspects of brain
development and function. In the adult brain, astrocytes are known to intimately ensheath …

In the neocortex, higher-order areas are essential to integrate sensory-motor information
and have expanded in size during evolution. How higher-order areas are specified …

Loss of Foxc1 is associated with Dandy-Walker malformation, the most common human
cerebellar malformation characterized by cerebellar hypoplasia and an enlarged posterior …

The hippocampus is a brain area central for cognition. Mutations in the human SOX2
transcription factor cause neurodevelopmental defects, leading to intellectual disability and …

During the development of the cerebral cortex, Cajal-Retzius (CR) cells settle in the preplate
and coordinate the precise growth of the neocortex. Indeed, CR cells migrate tangentially …

The ERK/MAPK pathway is an important developmental signaling pathway. Mutations in
upstream elements of this pathway result in neuro-cardio-facial cutaneous (NCFC) …