Reprogramming: emerging strategies to rejuvenate aging cells and tissues
Q Alle, E Le Borgne, O Milhavet… - International journal of …, 2021 - mdpi.com
Aging is associated with a progressive and functional decline of all tissues and a striking
increase in many “age-related diseases”. Although aging has long been considered an …
increase in many “age-related diseases”. Although aging has long been considered an …
Long-term culture of patient-derived cardiac organoids recapitulated Duchenne muscular dystrophy cardiomyopathy and disease progression
V Marini, F Marino, F Aliberti, N Giarratana… - Frontiers in Cell and …, 2022 - frontiersin.org
Duchenne Muscular Dystrophy (DMD) is an X-linked neuromuscular disease which to date
is incurable. The major cause of death is dilated cardiomyopathy however, its pathogenesis …
is incurable. The major cause of death is dilated cardiomyopathy however, its pathogenesis …
Atomic force spectroscopy is a promising tool to study contractile properties of cardiac cells
Abstract Atomic Force Microscopy (AFM) is a rather new method with increasing potential in
analyzing various biosamples. Moreover, it can serve as a multi-functional device in the …
analyzing various biosamples. Moreover, it can serve as a multi-functional device in the …
Calcium handling maturation and adaptation to increased substrate stiffness in human iPSC-derived cardiomyocytes: The impact of full-length dystrophin deficiency
JM Pioner, L Santini, C Palandri, M Langione… - Frontiers in …, 2022 - frontiersin.org
Cardiomyocytes differentiated from human induced Pluripotent Stem Cells (hiPSC-CMs) are
a unique source for modelling inherited cardiomyopathies. In particular, the possibility of …
a unique source for modelling inherited cardiomyopathies. In particular, the possibility of …
TRF2 rescues telomere attrition and prolongs cell survival in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs
A Eguchi, AFGS Gonzalez… - Proceedings of the …, 2023 - National Acad Sciences
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease caused by the
lack of dystrophin. Heart failure, driven by cardiomyocyte death, fibrosis, and the …
lack of dystrophin. Heart failure, driven by cardiomyocyte death, fibrosis, and the …
Full-length dystrophin deficiency leads to contractile and calcium transient defects in human engineered heart tissues
Cardiomyopathy is currently the leading cause of death for patients with Duchenne muscular
dystrophy (DMD), a severe neuromuscular disorder affecting young boys. Animal models …
dystrophy (DMD), a severe neuromuscular disorder affecting young boys. Animal models …
Tamoxifen treatment ameliorates contractile dysfunction of Duchenne muscular dystrophy stem cell-derived cardiomyocytes on bioengineered substrates
Duchenne muscular dystrophy (DMD) is a progressive genetic myopathy that leads to heart
failure from dilated cardiomyopathy by early adulthood. Recent evidence suggests that …
failure from dilated cardiomyopathy by early adulthood. Recent evidence suggests that …
Impact of neurons on patient-derived cardiomyocytes using organ-on-A-chip and iPSC biotechnologies
AA Bernardin, S Colombani, A Rousselot, V Andry… - Cells, 2022 - mdpi.com
In the heart, cardiac function is regulated by the autonomic nervous system (ANS) that
extends through the myocardium and establishes junctions at the sinus node and ventricular …
extends through the myocardium and establishes junctions at the sinus node and ventricular …
Ryanodine receptor dysfunction causes senescence and fibrosis in Duchenne dilated cardiomyopathy
Background Duchenne muscular dystrophy (DMD) is an X‐linked disorder characterized by
progressive muscle weakness due to the absence of functional dystrophin. DMD patients …
progressive muscle weakness due to the absence of functional dystrophin. DMD patients …
Aminophylline induces two types of arrhythmic events in human pluripotent stem cell–derived cardiomyocytes
S Klimovic, M Scurek, M Pesl, D Beckerova… - Frontiers in …, 2022 - frontiersin.org
Cardiac side effects of some pulmonary drugs are observed in clinical practice.
Aminophylline, a methylxanthine bronchodilator with documented proarrhythmic action, may …
Aminophylline, a methylxanthine bronchodilator with documented proarrhythmic action, may …