Reprogramming: emerging strategies to rejuvenate aging cells and tissues

Q Alle, E Le Borgne, O Milhavet… - International journal of …, 2021 - mdpi.com
Aging is associated with a progressive and functional decline of all tissues and a striking
increase in many “age-related diseases”. Although aging has long been considered an …

Long-term culture of patient-derived cardiac organoids recapitulated Duchenne muscular dystrophy cardiomyopathy and disease progression

V Marini, F Marino, F Aliberti, N Giarratana… - Frontiers in Cell and …, 2022 - frontiersin.org
Duchenne Muscular Dystrophy (DMD) is an X-linked neuromuscular disease which to date
is incurable. The major cause of death is dilated cardiomyopathy however, its pathogenesis …

Atomic force spectroscopy is a promising tool to study contractile properties of cardiac cells

D Kabanov, S Klimovic, V Rotrekl, M Pesl, J Pribyl - Micron, 2022 - Elsevier
Abstract Atomic Force Microscopy (AFM) is a rather new method with increasing potential in
analyzing various biosamples. Moreover, it can serve as a multi-functional device in the …

Calcium handling maturation and adaptation to increased substrate stiffness in human iPSC-derived cardiomyocytes: The impact of full-length dystrophin deficiency

JM Pioner, L Santini, C Palandri, M Langione… - Frontiers in …, 2022 - frontiersin.org
Cardiomyocytes differentiated from human induced Pluripotent Stem Cells (hiPSC-CMs) are
a unique source for modelling inherited cardiomyopathies. In particular, the possibility of …

TRF2 rescues telomere attrition and prolongs cell survival in Duchenne muscular dystrophy cardiomyocytes derived from human iPSCs

A Eguchi, AFGS Gonzalez… - Proceedings of the …, 2023 - National Acad Sciences
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease caused by the
lack of dystrophin. Heart failure, driven by cardiomyocyte death, fibrosis, and the …

Full-length dystrophin deficiency leads to contractile and calcium transient defects in human engineered heart tissues

SB Bremner, CJ Mandrycky, A Leonard, AR Levinson… - Biophysical …, 2022 - cell.com
Cardiomyopathy is currently the leading cause of death for patients with Duchenne muscular
dystrophy (DMD), a severe neuromuscular disorder affecting young boys. Animal models …

Tamoxifen treatment ameliorates contractile dysfunction of Duchenne muscular dystrophy stem cell-derived cardiomyocytes on bioengineered substrates

F Birnbaum, A Eguchi, G Pardon, ACY Chang… - NPJ Regenerative …, 2022 - nature.com
Duchenne muscular dystrophy (DMD) is a progressive genetic myopathy that leads to heart
failure from dilated cardiomyopathy by early adulthood. Recent evidence suggests that …

Impact of neurons on patient-derived cardiomyocytes using organ-on-A-chip and iPSC biotechnologies

AA Bernardin, S Colombani, A Rousselot, V Andry… - Cells, 2022 - mdpi.com
In the heart, cardiac function is regulated by the autonomic nervous system (ANS) that
extends through the myocardium and establishes junctions at the sinus node and ventricular …

Ryanodine receptor dysfunction causes senescence and fibrosis in Duchenne dilated cardiomyopathy

M Souidi, J Resta, H Dridi, Y Sleiman… - Journal of Cachexia …, 2024 - Wiley Online Library
Background Duchenne muscular dystrophy (DMD) is an X‐linked disorder characterized by
progressive muscle weakness due to the absence of functional dystrophin. DMD patients …

Aminophylline induces two types of arrhythmic events in human pluripotent stem cell–derived cardiomyocytes

S Klimovic, M Scurek, M Pesl, D Beckerova… - Frontiers in …, 2022 - frontiersin.org
Cardiac side effects of some pulmonary drugs are observed in clinical practice.
Aminophylline, a methylxanthine bronchodilator with documented proarrhythmic action, may …