Poly (N-isopropylacrylamide)-based thermoresponsive surfaces provide new types of biomedical applications

K Nagase, M Yamato, H Kanazawa, T Okano - Biomaterials, 2018 - Elsevier
Thermoresponsive surfaces, prepared by grafting of poly (N-isopropylacrylamide)(PIPAAm)
or its copolymers, have been investigated for biomedical applications. Thermoresponsive …

Stimuli-reponsive polymers and their bioconjugates

ES Gil, SM Hudson - Progress in polymer science, 2004 - Elsevier
Stimuli responsive polymers can provide a variety of applications for the biomedical fields.
The interest in these polymers has exponentially increased due to their promising potential …

Smart polymers: Physical forms and bioengineering applications

A Kumar, A Srivastava, IY Galaev… - Progress in polymer …, 2007 - Elsevier
Smart polymers (SP) have become one important class of polymers and their applications
have been increasing significantly. Last two to three decades have witnessed explosive …

Thermoresponsive interfaces obtained using poly (N-isopropylacrylamide)-based copolymer for bioseparation and tissue engineering applications

K Nagase - Advances in Colloid and Interface Science, 2021 - Elsevier
Abstract Poly (N-isopropylacrylamide)(PNIPAAm) is the most well-known and widely used
stimuli-responsive polymer in the biomedical field owing to its ability to undergo temperature …

Fabrications and applications of stimulus-responsive polymer films and patterns on surfaces: A review

JK Chen, CJ Chang - Materials, 2014 - mdpi.com
In the past two decades, we have witnessed significant progress in developing high
performance stimuli-responsive polymeric materials. This review focuses on recent …

Temperature-responsive intelligent interfaces for biomolecular separation and cell sheet engineering

K Nagase, J Kobayashi… - Journal of the Royal …, 2009 - royalsocietypublishing.org
Temperature-responsive intelligent surfaces, prepared by the modification of an interface
with poly (N-isopropylacrylamide) and its derivatives, have been used for biomedical …

Thermoresponsive-polymer-based materials for temperature-modulated bioanalysis and bioseparations

K Nagase, T Okano - Journal of Materials Chemistry B, 2016 - pubs.rsc.org
Many bioactive compounds, pharmaceutical proteins, and therapeutic cells are used in
medical treatments. Methods for the effective purification of such compounds that retain their …

A novel strategy to reinforce double network hydrogels with enhanced mechanical strength and swelling ratio by nano cement hydrates

H Wang, Z Lu, F Wang, Y Li, Z Ou, J Jiang - Polymer, 2023 - Elsevier
Nano-reinforcement has become a promising strategy to enhance the crosslinking
microstructure and mechanical properties of hydrogels. In this study, a new type of …

[PDF][PDF] 1, 2, 4-triazine analogs as novel class of therapeutic agents

R Kumar, TS Sirohi, H Singh, R Yadav… - Mini-Rev. Med …, 2014 - researchgate.net
Abstract: 1, 2, 4-Triazine nucleus is a prominent structural core system present in numerous
pharmacologically active compounds. Till date, various 1, 2, 4-triazine analogs, possesing a …

Temperature-responsive chromatography for bioseparations: A review

K Nagase, H Kanazawa - Analytica Chimica Acta, 2020 - Elsevier
In recent decades, in addition to existing small-molecule drug therapies, biomedical
technology has also rapidly progressed, leading to the development of various therapies …